CBD supplementation reduces arterial blood pressure via modulation of the sympatho-chromaffin system: A substudy from the HYPER-H21-4 trial - 26/02/23







Abstract |
Data concerning the effects of cannabidiol (CBD) on blood pressure (BP) is controversial. HYPER-H21–4 was a randomized, placebo-controlled, crossover trial which sought to elucidate if 5-week administration of CBD will reduce BP in hypertensive patients. In the substudy of this trial, we aimed to establish the mechanistic background of CBD-induced BP reduction. Specifically, we explored the dynamic of catestatin, a sympathoinhibitory peptide implicated in the pathophysiology of hypertension. In the present analysis, 54 patients with Grade 1 hypertension were included. 5-week administration of CBD but not placebo reduced serum catestatin concentration in comparison to baseline (13.50 [10.85–19.05] vs. 9.65 [6.37–12.26] ng/mL, p < 0.001). Serum catestatin levels at the start of the treatment period demonstrated a negative correlation with the extent of reduction in mean arterial pressure (r = −0.474, p < 0.001). Moreover, the extent of change in catestatin serum levels showed a strong correlation with the extent of mean arterial pressure reduction (r = 0.712, p < 0.001). Overall, the results of the present study imply that the antihypertensive effects of CBD may be explained by its interaction with the sympatho-chromaffin system, although further research is warranted.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | CBD supplementation reduces office blood pressure (BP) and serum catestatin levels. |
• | The extent of BP reduction correlates with the reduction in serum catestatin levels. |
• | Baseline catestatin levels may predict the extent of CBD-associated BP reduction. |
Keywords : Catestatin, Hypertension, CBD
Plan
Vol 160
Article 114387- avril 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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