Investigating modifiable pathways in psoriasis: A Mendelian randomization study - 24/02/23
, Andrea Georgiou, PhD a, Emmanouil Bouras, MSc a, Evangelos Evangelou, PhD a, b, c, Dipender Gill, PhD b, Kostas K. Tsilidis, PhD a, b, Ioanna Tzoulaki, PhD a, b, c, dAbstract |
Background |
Potentially modifiable risk factors have previously been investigated only in conventional observational studies.
Objective |
To assess whether genetically predicted exposures to modifiable factors are associated with the risk of psoriasis.
Methods |
Two-sample Mendelian randomization (MR) analysis.
Results |
An increased risk of psoriasis was noted for genetically predicted lifetime smoking index (odds ratio [OR]MR-IVW = 2.11; 95% confidence interval [CI], 1.28-3.51), childhood (OR MR-IVW = 1.40; 95% CI, 1.14-1.71) and adult body mass index (OR MR-IVW = 1.63; 95% CI, 1.32-2), waist (OR IVW = 1.86; 95% CI, 1.31-2.64), and hip circumference (OR MR-IVW = 1.55; 95% CI, 1.15-2.07). Protective association was also reported between genetically predicted longer sleep duration (OR MR-IVW = 0.56; 95% CI 0.37-0.84) and increased years of education (OR MR-IVW = 0.78; 95% CI, 0.62-0.98). This effect of education persisted in multivariable MR after adjusting for genetic predictors of smoking and adult body mass index (ORMVMR-IVW = 0.72; 95% CI, 0.56-0.92).
Limitations |
It was not possible to stratify for psoriasis severity.
Conclusion |
Smoking cessation and prevention of obesity are important strategies for decreasing the incidence of psoriasis. Similarly, targeting education inequality is expected to lead further to reductions in cases of psoriasis.
Le texte complet de cet article est disponible en PDF.Abbreviations used : BMI, CI, MR, MVMR, OR, SD, IV, IVW, GWAS
Key words : epidemiology, genetics, Mendelian randomization, modifiable factors, psoriasis, risk
Plan
| Funding sources: This study was funded by the Operational Programme “Competitiveness, Entrepreneurship & Innovation” (OΠΣ 5047228). |
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| IRB approval status: Not applicable. |
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| Patient consent: Not applicable. |
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| Data availability statement: Summary statistics of potential risk factors could be downloaded from the GWAS catalogue (gwas/). Summary statistics of psoriasis are not publicly available but can be obtained from the corresponding author of the GWAS study on reasonable request. |
Vol 88 - N° 3
P. 593-601 - mars 2023 Retour au numéro
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