Necrotising soft-tissue infections - 23/02/23

Doi : 10.1016/S1473-3099(22)00583-7

Camille Hua, MD ^a,^d,^e,^f, Tomas Urbina, MD ^g, Romain Bosc, MD ^b, Tom Parks, MD ^h, Shiranee Sriskandan, ProfPhD ^h,ⁱ, Nicolas de Prost, ProfMD ^c,^j,^{^{†
Contributed equally as last authors}}, Olivier Chosidow, ProfMD ^a,^d,^f,^k,^{^{†
Contributed equally as last authors},}⁎

^a Service de Dermatologie, Assistance Publique-Hôpitaux de Paris, Créteil, France

^b Service de Chirurgie Plastique, Assistance Publique-Hôpitaux de Paris, Créteil, France

^c Service de Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Paris, Créteil, France

^d Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France

^e Epidemiology in Dermatology and Evaluation of Therapeutics, Université Paris Est Créteil, Créteil, France

^f Groupe Infectiologie Dermatologique—Infections Sexuellement Transmissibles, Société Française de Dermatologie, Paris, France

^g Service de Médecine Intensive Réanimation, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France

^h Department of Infectious Diseases, Imperial College London, London, UK

ⁱ MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK

^j CARMAS Research Group, UPEC-Université Paris-Est Créteil Val de Marne, Faculté de médecine de Créteil, Créteil, France

^k Research group Dynamyc, Faculté de Santé de Créteil, Ecole Nationale Vétérinaire d’Alfort, USC ANSES, Université Paris-Est Créteil, Créteil, France

^* Correspondence to: Prof Olivier Chosidow, Service de Dermatologie, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France Service de Dermatologie Hôpitaux Universitaires Henri Mondor Assistance Publique-Hôpitaux de Paris Créteil 94010 France

Summary

The incidence of necrotising soft-tissue infections has increased during recent decades such that most physicians might see at least one case of these potentially life-threatening infections in their career. Despite advances in care, necrotising soft-tissue infections are still associated with high morbidity and mortality, underlining a need for continued education of the medical community. In particular, failure to suspect necrotising soft-tissue infections, fuelled by poor awareness of the disease, promotes delays to first surgical debridement, amplifying disease severity and adverse outcomes. This Review will focus on practical approaches to management of necrotising soft-tissue infections including prompt recognition, initiation of specific management, exploratory surgery, and aftercare. Increased alertness and awareness for these infections should improve time to diagnosis and early referral to specialised centres, with improvement in the prognosis of necrotising soft-tissue infections.

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Vol 23 - N° 3

P. e81-e94 - mars 2023 Retour au numéro

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Necrotising soft-tissue infections - 23/02/23

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