Differences in biomarker concentrations in serum and urine of patients with Ocular Tuberculosis – A prospective descriptive study - 25/01/23
, Candice Snyders b , Gerhard Walzl b , Novel Chegou b , Derrick Smit a, ⁎ Abstract |
Purpose |
To describe biomarker concentrations in serum and urine of South African patients with ocular tuberculosis (OTB).
Methods |
A prospective study to compare 29 urine and serum biomarkers in 14 OTB patients at a tertiary eye clinic.
Results |
Median age of participants (7 male and 7 female) was 38.5 years (range 25–73) Most biomarker concentrations were significantly higher in serum than in urine (p < 0.01). Only 2 (IL-1RA and IL-2) showed higher concentrations in urine than serum (p < 0.01). Three biomarkers (sIL-2Ra, sTNFRI and IFNγ) showed no difference in concentration between urine and serum (p > 0.05).
Conclusions |
Most biomarkers tested showed significant differences in concentration between serum and urine and therefore these 2 biofluids cannot be used interchangeably when studying biomarker profiles. One notable exception is IFNγ as its concentration did not differ between serum and urine.
Le texte complet de cet article est disponible en PDF.Keywords : Biomarker, Ocular tuberculosis, South Africa, Serum, Urine
Plan
Vol 138
Article 102290- janvier 2023 Retour au numéro
Article précédent
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