Gut microbiota might influence the risk of rejection after liver transplantation - 15/01/23
, Stoma Igor Olegovich b, Kovalev Aliaksei Aliakseevich c, Hubanova Tatiana Nikolaevna a, Fedoruk Aliaksei Mikhailovich a, Shcherba Aliaksei Eugenievich a, Oleg Olegovich Rummo a
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Highlights |
• | In recent years, there has been a steady increase in researches devoted to the impact of gut microbiota, both on the course of chronic liver disease progression and the results of liver transplantation. |
• | Our study revealed significant differences between patients with and without acute graft rejection according to the taxa Protobacteria (p = 0.001), (median values for the group with and without rejection: 0.09 [0.06, 0.21] and 0.02 [0.01, 0.04]), respectively;. |
• | A statistically significant difference in the taxon Candidatus saccharibacteria (p = 0.04) revealed in our study should be noted. The detection of differences in Candidatus Saccharibacteria, previously classified as TM7, between patients with and without AR episodes is of great academic and clinical interest. |
• | Obtained results prove a reliable interaction between gut microbiota and the incidence of acute liver graft rejection in dominant taxa and Candidatus saccharibacteria that had not yet been observed in patients with rejection episodes. |
• | Thus, it is clear that gut microbiota can be used as an important tool in predicting early liver graft rejection. |
Abstract |
Introduction |
Liver transplantation is the only radical treatment option available for patients with end-stage chronic liver disease. However, severe post-transplant complications remain relevant, including acute graft rejection and infection. Thus, the impact of gut microbiota on the frequency of these complications is highly promising.
Materials and methods |
This prospective, cohort, closed-label study included 24 adults who underwent liver transplantation. The mean age was 49.2 ± 13.4 years; Child-Turcotte-Pugh A, B, and C classes were distributed as follows: A: 8 (33.3%); B: 11 (45.8%); C: 5 (20.8%). Gut microbiota was evaluated using 16S RNA new-generation sequencing.
Study registration |
NCT04281797.
Results |
According to etiological distribution, significant differences were observed in the number of Firmicutes (p = 0.03) and Chlorobi (p = 0.009) harbored by the patients of alcoholic liver disease. Similarly, the severity of hepatic decompensation varied significantly for patients harboring Chlorobi (p = 0.01) and coprothermobacterota (p = 0.03). The association between sarcopenia and the microbiota was not significant among all taxa (p>0.1). Acute graft rejection differences between groups were found: Protobacteria (p = 0.001); Chlamydiae (p = 0.02); Gammaproteobacteria (p = 0.01); Chloroflexia (p = 0.004); Chlamydiia (p = 0.01); Enterobacteriaceae (p = 0.001); and Candidatus Saccharibacteria (p = 0.04), the median of which was found to be lower in patients with an acute graft rejection episode.
Conclusions |
Obtained results prove a reliable interaction between gut microbiota and the incidence of acute liver graft rejection in dominant taxa and Candidatus Saccharibacteria that had not yet been observed in patients with rejection episodes.
Le texte complet de cet article est disponible en PDF.Keywords : Chronic liver disease, Liver cirrhosis, Liver transplantation, Acute rejection episode, Post-transplant
Abbreviations : ACLF, ALD, AR, CLD, GM, LC, LT, NAFLD, NASH, POD
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Vol 9
Article 100140- février 2023 Retour au numéro
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