Sanwei sandalwood decoction ameliorates acute ischemia-reperfusion injury in rats by modulating myocyte electrophysiological characteristics - 13/01/23
, QingShan Zhang a, b, d, ⁎ Abstract |
Sanwei sandalwood decoction (SWTX) is a classical Chinese medicine formula and clinically effective treatment for coronary heart disease, including myocardial ischemia/reperfusion (I/R) injury. Because the treatment mechanism of SWTX in I/R injury remains obscure, we intended to analyze the potential cardioprotective effects of SWTX in rats with myocardial I/R injury. Our research revealed that SWTX prolonged ventricular conduction time in a dose-dependent manner. While SWTX significantly delayed left ventricular signal conduction velocity, it had no effect on left atrial conduction velocity. Under sinus conditions, low SWTX concentrations reduced left ventricular conduction dispersion, while high concentrations increased conduction dispersion. SWTX also prolonged the QRS interval, APD30/50/90, and ERP. In whole-cell patch clamp experiments on myocytes, Ito and Ikr were inhibited by SWTX. While SWTX had no effect on INa, the activation curve for Nav1.5 was left-shifted. Finally, SWTX reduced the probability of ventricular fibrillation and suppressed early and late depolarization in an acute I/R injury rat model. These findings shed light on the mechanism by which SWTX alleviates myocardial I/R injury.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Possible protective mechanism of SWTX in acute ischemia-reperfusion injury.
Possible protective mechanism of SWTX in acute ischemiareperfusion injury.ga1Le texte complet de cet article est disponible en PDF.
Highlights |
• | SWTX protects heart from I/R injury in vivo. |
• | SWTX prolonged ventricular conduction, influenced left ventricular conduction dispersion, prolonged the QRS interval, APD30/50/90, and ERP. |
• | SWTX inhibited Ito and Ikr and left-shifted the activation curve for Nav1.5. |
Abbreviations : I/R, SWTX, CVD, HAPH, SPF, SD, INa, Ito, IKr
Keywords : Ischemia/reperfusion injury, Sanwei sandalwood decoction, Electrophysiological characteristics
Plan
Vol 158
Article 114103- février 2023 Retour au numéro
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