Phototheranostics for NIR fluorescence image guided PDT/PTT with extended conjugation and enhanced TICT - 13/01/23
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Abstract |
Introducing donor and acceptor into conjugated system can facilitate the intersystem crossing (ISC) rate to increase the generation of ROS. Twisted intramolecular charge transfer (TICT) state could favor enhance the nonradiative transition and photothermal conversion efficiency (PCE). Herein, diketopyrrolopyrrole (DPP) core functionalized benzene (PDDP), thiophene (TDPP), triphenylamine-conjugated benzene (TPA-PDDP) and thiophene (TPA-TDPP) derivatives were designed and synthesized. Electrochemistry experiments revealed the heavy atom effect and the introduction of triphenylamine reduced the energy level of TPA-TDPP and improved the ability to generate 1O2 (1O2 QY = 50%). In addition, in the aggregated state, introduction of thiophene, triphenylamine, and long alkyl chains promoted the twisting effect, preventing the intermolecular π-π interaction and enhancing the PCE of TPA-TDPP (38.7%). In vivo fluorescence imaging showed that TPA-TDPP NPs can target the tumor site with the enhanced permeability and retention (EPR) effect and presented excellent synergistic photodynamic/photothermal therapy.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Extending conjugation and enhancing TICT can enhance PDT and PTT. |
• | Molecular rotor triphenylamine facilitated ISC rate and stabilized TICT state. |
• | TPA-TDPP possesses great photothermal conversion efficiency (38.7%). |
• | TPA-TDPP possesses great 1O2 production capacity (50%). |
• | Fluorescence imaging/thermal imaging and multitherapy induce the potential application on anticancer. |
Keywords : Phototheranostics, NIR fluorescence, Photodynamic therapy, Photothermal therapy
Plan
Vol 158
Article 114071- février 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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