Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway - 13/01/23
![](/templates/common/images/mail.png)
![](/templates/common/images/mail.png)
![](/templates/common/images/mail.png)
Abstract |
Alzheimer's disease (AD) has become a major public health problem affecting the elderly population, and there is currently no effective treatment. Although the pathogenesis of AD is unclear, neurotoxicity induced by oxidative stress plays an important role in the progression of AD. Ginseng, the root and rhizome of Panax ginseng C. A. Meyer, is used not only as an herbal medicine but also as a functional food to support bodily functions. Ginsenoside Rk3 (Rk3), the main bioactive component in ginseng, has a strong antioxidant effect and has not been reported in AD. In this study, we showed that Rk3 improved neuronal apoptosis, decreased intracellular reactive oxygen species (ROS) production and restored mitochondrial membrane potential in PC12 and primary neuronal cells. In vivo, we found that Rk3 improved spatial learning and memory deficit in precursor protein (APP)/presenilin 1 (PS1) double transgenic mouse model of AD. Additionally, Rk3 increases glutathione reductase (GSH) and superoxide dismutase (SOD) levels while inhibits malondialdehyde (MDA) production, apoptosis and activation of glial cells in APP/PS1 mice. Mechanistically, we found that the protective effect of Rk3 is in correlation with the activation of AMPK/Nrf2 signaling pathway. In conclusion, the findings of this study provide support for Rk3 as a new strategy for the treatment of AD.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Ginsenoside Rk3, a bioactive component in ginseng, exhibits neuroprotective effects in PC12 cells and primary neuronal cells. |
• | Rk3 significantly alleviates AD pathology with the therapeutic effect better than that of donepezil. |
• | The protective effect of Rk3 is associated with the activation of AMPK/Nrf2 signaling pathway. |
• | Ginsenoside Rk3 is expected to be a potential therapeutic drug for AD. |
Keywords : Alzheimer’s disease, Ginsenoside Rk3, Oxidative stress, APP/PS1, AMPK signaling pathway
Abbreviations : AD, APP, APP/PS1, MDA, GSH, SOD, ROS, RK3, BACE1, NFTs, NOR, MWM, TBA, HO-1, LDH, MAP2, PSD95, GFAP, TCM, Nrf2, NQO1
Plan
Vol 158
Article 114192- février 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?