A distinct phylogenetic cluster of Monkeypox genomes suggests an early and cryptic spread of the virus - 24/12/22
Doi : 10.1016/j.jinf.2022.08.013
Bani Jolly a, b, Vinod Scaria a, b, ⁎ 
a CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, New Delhi, India
b Academy for Scientific and Innovative Research, Human Resource Development Centre Campus, Ghaziabad, Uttar Pradesh, India
⁎Corresponding author at: G. N. Ramachandran Knowledge Centre for Genome Informatics, CSIR-Institute of Genomics and Integrative Biology, Sukhdev Vihar, New Delhi 110025, India.G. N. Ramachandran Knowledge Centre for Genome InformaticsCSIR-Institute of Genomics and Integrative Biology, Sukhdev ViharNew Delhi110025India
Highlights |
• | Genomes from 3 different countries form a distinct lineage A.2 of the monkeypox virus. |
• | Lineage A.2 is distinctly different from the B.1 lineage linked to the European outbreak. |
• | A.2 genomes have 16 genetic variations which are not found in other lineages. |
• | Lineage A.2 has a median tMRCA of 25 June 2021 and a lower nucleotide substitution rate than B.1 lineage. |
• | Cases associated with A.2 lineage were linked to travel to either Nigeria or the UAE. |
Keywords : Monkeypox, 2022 Outbreak, Lineage A.2, Lineage B.1
Plan
© 2022
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 86 - N° 1
P. e24-e26 - janvier 2023 Retour au numéro
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