Early seasonal coronavirus seroconversion did not produce cross-protective SARS-CoV-2 antibodies - 24/12/22
Doi : 10.1016/j.jinf.2022.08.032
Lydia Su Yin Wong a, b, ⁎ 
, Evelyn Xiu Ling Loo a, c, Chiung-Hui Huang a, Gaik Chin Yap a, Michelle Jia Yu Tay a, Regena Xin Yi Chua a, Alicia Yi Hui Kang a, Liangjian Lu b, Bee Wah Lee a, Lynette Pei-Chi Shek a, c, Jinyan Zhang d, Wan Ni Chia d, Lin-Fa Wang d, Elizabeth Huiwen Tham a, b, c, e, Paul Anantharajah Tambyah f, g
, Evelyn Xiu Ling Loo a, c, Chiung-Hui Huang a, Gaik Chin Yap a, Michelle Jia Yu Tay a, Regena Xin Yi Chua a, Alicia Yi Hui Kang a, Liangjian Lu b, Bee Wah Lee a, Lynette Pei-Chi Shek a, c, Jinyan Zhang d, Wan Ni Chia d, Lin-Fa Wang d, Elizabeth Huiwen Tham a, b, c, e, Paul Anantharajah Tambyah f, g a Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
b Khoo Teck Puat-National University Children's Medical Institute, National University Health System
c Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR)
d Duke-NUS Medical School
e Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore
f National University Hospital, Singapore
g Department of Medicine, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore
⁎Corresponding author at: Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore 119228, Singapore.Department of Paediatrics, Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge Road, NUHS Tower Block, Level 12Singapore119228Singapore
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Highlights |
• | Seropositivity to endemic human coronaviruses (HCoV) differs by age. |
• | Seropositivity rises in early life, increases in adolescence; declines in adulthood. |
• | No cross neutralization of SARS-CoV-2 despite high seropositivity to endemic HCoV. |
Graphical abstract |
Keywords : Antibodies, Coronavirus, Cross-neutralization, Seroconversion, Seroprevalence
Abbreviations : HCoV
Plan
© 2022
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 86 - N° 1
P. e10-e12 - janvier 2023 Retour au numéro
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