Long-term childhood outcomes for babies born at term who were exposed to antenatal corticosteroids - 22/12/22
Abstract |
Background |
Antenatal corticosteroids improve neonatal outcomes when administered to infants who are at risk of preterm delivery. Many women who receive antenatal corticosteroids for threatened preterm labor proceed to deliver at term. Thus, long-term outcomes should be evaluated for term-born infants who were exposed to antenatal corticosteroids in utero.
Objective |
This study aimed to compare long-term outcomes between term-born children aged ≥5 years who were born to women who received antenatal corticosteroids for threatened preterm labor and children whose mothers were also evaluated for threatened preterm labor but did not receive antenatal corticosteroids.
Study Design |
We performed a retrospective cohort study of children born at ≥37 weeks’ gestation, aged ≥5 years, and born to mothers diagnosed with threatened preterm labor during pregnancy. The primary exposure of interest was receiving antenatal corticosteroids. Among the collected childhood medical conditions, the primary outcome of interest was a diagnosis of asthma.
Results |
Of the 3556 term-born children aged ≥5 years, 629 (17.6%) were exposed to antenatal corticosteroids (all betamethasone), and 2927 (82.3%) were controls whose mothers were evaluated for threatened preterm birth but did not get antenatal corticosteroid injections. Women receiving antenatal corticosteroids had higher rates of maternal comorbidities (diabetes mellitus, hypertension; P≤.01). Antenatal corticosteroid-exposed children had no difference in diagnosis of asthma (12.6% vs 11.6%), attention deficit disorder, or developmental delay (P=.47, .54, and .10, respectively). Controlling for maternal and neonatal characteristics, asthma was not different between those exposed to antenatal corticosteroids and controls (odds ratio, 1.05; 95% confidence interval, 0.79–1.39). The odds of the child’s weight percentile being <10% were increased for antenatal corticosteroid-exposed children born at term (odds ratio, 2.00; 95% confidence interval, 1.22–3.25).
Conclusion |
Children born at term who were exposed to antenatal corticosteroids may have increased odds of being in a lower growth percentile than those not exposed. However, rates of diagnoses such as asthma, developmental delay, and attention deficit disorders were not different.
Le texte complet de cet article est disponible en PDF.Key words : antenatal corticosteroids, asthma, attention deficit disorder, developmental delay, growth percentile, threatened preterm birth, weight percentile
Plan
| The authors report no conflict of interest. |
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| This study was funded, in part, with support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD088014 to D.M.H.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Support was also provided by the Indiana University School of Medicine Department of Obstetrics and Gynecology to the Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health (PREGMED). |
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| Cite this article as: Osteen SJ, Yang Z, McKinzie AH, et al. Long-term childhood outcomes for babies born at term who were exposed to antenatal corticosteroids. Am J Obstet Gynecol 2023;228:80.e1-6. |
Vol 228 - N° 1
P. 80.e1-80.e6 - janvier 2023 Retour au numéro
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