Trends in surgery and survival for T1-T2 male breast cancer: A study from the National Cancer Database - 13/12/22
Abstract |
Background |
Despite evidence that early-stage male breast cancer (MBC) can be treated the same as in females, we hypothesized that men undergo more extensive surgery.
Methods |
Patients with clinical T1-2 breast cancer were identified in the National Cancer Database 2004–2016. Trends in surgery type and overall survival were compared between sexes.
Results |
Of 9,782 males and 1,078,105 females, most were cN0 with AJCC stage I/II disease. Unilateral mastectomy was most common in men (67.1% vs. 24.1%, p < 0.001) and partial mastectomy in women (64.7% vs. 26.4%, p < 0.001), with no significant change over time. Over 1/3 of men received ALND in 2016. While overall survival was superior in females (HR 0.83, 95% CI 0.73–0.94, p = 0.003), partial mastectomy was associated with a 42% reduction in mortality risk for males (HR 0.58, 95% CI 0.4–0.8, p = 0.003).
Conclusions |
De-escalation of surgery could be considered for MBC to improve survival and align with current standards of care.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Men continue to undergo more extensive surgery for T1-T2 breast cancer than women. |
• | Unilateral mastectomy rates for men have increased from 2004 to 2016. |
• | Males had inferior survival after adjustment for patient, tumor, and treatment factors. |
• | Partial mastectomy was associated with a 42% reduction in mortality risk for men. |
• | Surgical de-escalation could be considered in MBC and may improve outcomes. |
Keywords : Male breast cancer, Early stage breast cancer, Breast surgery, Axillary surgery, Survival outcomes, Gender disparities, Treatment trends
Abbreviations : MBC, BCS, MRM, SLNB, ALND
Plan
Vol 225 - N° 1
P. 75-83 - janvier 2023 Retour au numéro
Article précédent
- Utilization of a rapid diagnostic centre during the COVID-19 pandemic reduced diagnostic delays in breast cancer
- Gary Ko, Sangita Sequeira, David R. McCready, Sharmy Sarvanantham, Nancy Li, Shelley Westergard, Vrutika Prajapati, Vivianne Freitas, Tulin D. Cil
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- Marguerite M. Rooney, Samantha M. Thomas, Mahsa Taskindoust, Rachel A. Greenup, Laura H. Rosenberger, E. Shelley Hwang, Jennifer K. Plichta
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