Survival in patients with neuroendocrine tumors of the colon, rectum and small intestine - 13/12/22
Abstract |
Background |
Neuroendocrine neoplasms (NENs) of the colon, rectum and small intestine (SI) are increasing in incidence and prevalence. We evaluated the 5-year overall survival (OS), and cancer-specific survival (CSS).
Methods |
The Surveillance, Epidemiology, and End Results (SEER) 18 registry from 2000 to 2017 was accessed to identify patients with colonic, rectal, and SI NENs.
Results |
46,665 patients were diagnosed with NENs of the colon (n = 10,518, 22.5%), rectum (18,063, 38.7%), and SI (18,084, 38.8%). By tumor site alone, patients with well-differentiated neuroendocrine tumors (NETs) of the rectum had improved 5-year OS (HR 0.72, 95% CI 0.68–0.77, p < 0.001). However, patients with rectal poorly-differentiated neuroendocrine carcinomas (NECs) who underwent oncologic resection had lower 5-year OS (35.1%) compared to colon (41.9%), and SI (72.5%).
Conclusions |
Surgical resection may improve 5-year OS for NECs of the SI and colon, except in the rectum where survival was reduced. More frequent surveillance and timely initiation of systemic therapy should be considered for rectal NECs.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Associated increase in survival of rectal well-differentiated neuroendocrine tumors, compared to colon and small intestine. |
• | Rectal neuroendocrine tumor site of origin associated with improved 5-year overall survival. |
• | Reduced 5-year overall survival with age > 80, males, distant disease, and poorly-differentiated neuroendocrine carcinomas. |
• | Associated reduction in survival of rectal poorly-differentiated neuroendocrine carcinomas after resection. |
Plan
Vol 225 - N° 1
P. 58-65 - janvier 2023 Retour au numéro
Article précédent
- Individual components of post-hepatectomy care pathways have differential impacts on length of stay
- Allison N. Martin, Seth J. Concors, Bradford J. Kim, Timothy E. Newhook, Elsa M. Arvide, Whitney L. Dewhurst, Yoshikuni Kawaguchi, Hop S. Tran Cao, Matthew H.G. Katz, Jean-Nicolas Vauthey, Ching-Wei D. Tzeng
- Risk factors for prolonged hospitalization and readmission after total thyroidectomy in children: Associations with surgical subspecialty
- Christopher W. Snyder, Sacha A. Williams, Paul D. Danielson, Nicole M. Chandler
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?