Wounds under diabetic milieu: The role of immune cellar components and signaling pathways - 08/12/22
, Mingmei Zhou a, b, ⁎ , Cheng Zhao a, ⁎ Abstract |
A major challenge in the field of diabetic wound healing is to confirm the body's intrinsic mechanism that could sense the immune system damage promptly and protect the wound from non-healing. Accumulating literature indicates that macrophage, a contributor to prolonged inflammation occurring at the wound site, might play such a role in hindering wound healing. Likewise, other immune cell dysfunctions, such as persistent neutrophils and T cell infection, may also lead to persistent oxidative stress and inflammatory reaction during diabetic wound healing. In this article, we discuss recent advances in the immune cellular components in wounds under the diabetic milieu, and the role of key signaling mechanisms that compromise the function of immune cells leading to persistent wound non-healing.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
A variety of immune cells (Macrophages, Neutrophils, T cells, MDSCs, MCs, DCs, and DETCs, etc) in the body are impaired in the chronic hyperglycemic milieu environment, as well as the related signal pathways, thus affecting the wound healing of diabetes, The selection of effective targets in immune cells depends on the classification of diabetes, which informs immunotherapeutic strategies for diabetic wound healing.
A variety of immune cells (Macrophages, Neutrophils, T cells, MDSCs, MCs, DCs, and DETCs, etc) in the body are impaired in the chronic hyperglycemic milieu environment, as well as the related signal pathways, thus affecting the wound healing of diabetes, The selection of effective targets in immune cells depends on the classification of diabetes, which informs immunotherapeutic strategies for diabetic wound healing.ga1Le texte complet de cet article est disponible en PDF.
Highlights |
• | Focusing on immune cell dysfunction provides an emerging treatment for diabetic wounds. |
• | Immune mediators shed light on the mystery of what diabetic wounds will happen or have occurred. |
• | Immunotherapy for wounds relies on the type of diabetes, yet chronic hyperglycemic milieu matters. |
Abbreviations : A2R, AA, AGEs, BMDCs, COX, cPLA2, DCs, DETCs, DFUs, DIO, DNMAML, DNMT, DW, ECM, EGF, EP, GFP, H3K4, HDACs, ICAM-1, IGF-1, IL, KLF, LADA, LPS, LTB4, Ly6C, Ly6CLo, Ly6CHi, MAML, MCs, MCS, MDSCs, MLL1, mTOR, NETs, NF-кB, NICD, NLRP3, PAD4, PGE2, PI3K, PKB, PPAR, Rac-1, RAGE, ROS, SETDB2, SLC7A11, SPMs, STAT1, T1D, T2D, TCR, TGF, TLR, TNF, Treg, VCAM-1, VEGF
Keywords : Immune cells, Inflammation, Diabetes, Diabetic wound healing progression, Cellular components, Signaling pathways
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Vol 157
Article 114052- janvier 2023 Retour au numéro
Article précédent
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