Drug repurposing: Clemastine fumarate and neurodegeneration - 08/12/22
, Rong Ma b, ⁎ , Gang Li a, ⁎ Abstract |
Neurodegenerative diseases have been a weighty problem in elder people who might be stricken with motor or/and cognition defects with lower life quality urging for effective treatment. Drugs are costly from development to market, so that drug repurposing, exploration of existing drugs for novel therapeutic purposes, becomes a wise and popular strategy to raise new treatment options. Clemastine fumarate, different from anti-allergic effect as H1 histamine antagonist, was screened and identified as promising drug for remyelination and autophagy enhancement. Surprisingly, fumarate salt also has similar effect. Hence, whether clemastine fumarate would make a protective impact on neurodegenerative diseases and what contribution fumarate probably makes are intriguing to us. In this review, we summarize the potential mechanism surrounding clemastine fumarate in current literature, and try to distinguish independent or synergistic effect between clemastine and fumarate, aiming to find worthwhile research direction for neurodegeneration diseases.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Clemastine fumarate was identified as autophagy activator to dispose of intracellular redundant protein. |
• | Clemastine fumarate has ability to suppress inflammation no matter in peripheral system or central nervous system. |
• | Clemastine fumarate could give oligodendrocytes access to differentiation helping form myelin sheath. |
• | Clemastine fumarate is a hopeful agent for neurodegeneration and deserves further investigation. |
Abbreviations : Ach, AD, ALS, APP, Aβ, BACE1, BBB, CHRM1, Cle-F, CNPase, DMF, EAE, ER, FUS, G93A, iNOS, KO, LAMP2A, L-DOPA, MBP, MIRI, MMF, MOG, MPTP, MS, mTORC1, NFTs, NO, NRF2, Olig1, OLs, OPCs, PCA, PD, PLP, RNS, ROS, RRMS, SOD, TDP-43, TMN, VEPs
Keywords : Clemastine, Dimethyl fumarate, Remyelination, Autophagy, Neurodegeneration
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Vol 157
Article 113904- janvier 2023 Retour au numéro
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