The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring - 01/12/22
, Mei Zhu d, Meina Yang a, Xiaoyang Shen a, Xiaoyan Luo a, b, c, Li Ma a, e, Liangzhi Xu a, b, c, Jing Zhang a, b, c, ⁎ Abstract |
Background |
Maternal exposure to dibutyl phthalate (DBP) may result in obesity in female offspring. However, the underlying mechanisms remain elusive.
Materials and methods |
Sprague-Dawley rats were intraperitoneally injected with different doses of DBP and corn oil from gestational day 7 until the end of lactation. The weights, visceral fat percentage, serum lipid, insulin and glucose, protein levels of PI3K signal pathway in muscle were detected in F1 female offspring.
Results |
Although the birth weight of F1 female offspring was not different among groups, the weights were heavier in DBP groups from postnatal day 7 to adult (P < 0.001). The visceral adipose percentage in adult female offspring was increased by perinatal exposure to DBP (P < 0.001). Decreased serum level of triglyceride (P = 0.001) in F1 female offspring was found in DBP group as compared to control, especially in medium and high DBP. However, none difference was found for fasting glucose, prolactin, HOMA-IR, fasting insulin, total cholesterol, adiponectin. Different protein levels of GPR30 were observed in muscle of female offspring among four groups (P = 0.016). The protein level of AKT seemed higher in DBP group but without statistical significance (P = 0.05). None difference was observed for the protein levels of PI3K, p-AKT, pAKT/AKT, PTEN, GLUT4, InsR, IRS.
Conclusion |
Maternal perinatal exposure to DBP might induce obesity and accumulation of visceral adipose tissue for the adult female offspring. Serum glucolipid and local signal transduction of PTEN/PI3K/AKT pathway in muscle were not adversely affected by perinatal exposure to DBP for adult female offspring.
Le texte complet de cet article est disponible en PDF.Abbreviations : DBP, PND, Tch, TG, FG, PRL, FINS, ADP, ELISA, HOMA-IR, InsR, IRS-1, PI3K, p-AKT, GLUT4, PTEN, GRP30, BCA, PVDF, SD, ANOVA, PPAR
Keywords : Dibutyl phthalate, Obesity, Visceral fat, Glucolipid metabolism, PI3K, PTEN
Plan
Vol 16 - N° 6
P. 500-506 - novembre 2022 Retour au numéro
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