Weight loss and all-cause mortality: A propensity score matching cohort study - 01/12/22
Abstract |
Background |
Weight loss was supposed to help with decreasing risk of premature mortality. However, results on this topic remain debatable and limited by study design.
Objective |
The present study aimed to investigate the association between weight loss and all-cause mortality among US adults with overweight or obesity in a national cohort study by using propensity score matching (PSM) analysis.
Methods |
A total of 5486 pairs of participants were matched in the National Health and Nutrition Examination Survey (NHANES, 2003–2015) after PSM. Hazard ratios (95% confidence intervals) (HRs (95% CIs)) were employed to evaluate the association between weight loss indicated by long-term weight loss (LTWL) and all-cause mortality by using Cox proportional hazards regression models.
Results |
During a median follow-up of 6.8 years, 674 participants died from all-cause mortality. In each PSM match, compared with participants with LTWL < 5%, the HRs (95% CIs) for participants with LTWL of 5–9.9% (2877 pairs), 10–14.9% (1315 pairs), and ≥ 15% (1294 pairs) were 1.18 (0.83–1.68) (P = 0.366), 1.65 (1.17–2.34) (P = 0.005), and 1.91 (1.21–3.00) (P = 0.006), respectively. The significant increased risk of all-cause mortality for LTWL ≥ 15% remained among male, female, participants aged ≥ 65 years, without weight loss intention, with non-communicable diseases, and without exceeding estimated energy requirement.
Conclusion |
Weight loss especially for being ≥ 15% should be cautious for US adults with overweight or obesity.
Le texte complet de cet article est disponible en PDF.Keywords : Overweight or obesity, Weight loss, Mortality, Propensity score matching
Plan
Vol 16 - N° 6
P. 476-483 - novembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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