Aneuploidy underlies paradoxical growth of rezafungin and enables cross-tolerance to echinocandins in Candida albicans - 29/11/22
Doi : 10.1016/j.jinf.2022.09.028
Hao Li a, b, Yong-bing Cao c, Tian-hua Yan b, Yuan-ying Jiang a, ⁎ 
, Feng Yang a, ⁎
, Feng Yang a, ⁎ a Department of Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
b Department of Physiology and Pharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China
c Institute of Vascular Disease, Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
⁎Corresponding authors.
Highlights |
• | There is paradoxical effect for rezafungin, a new echinocandins drug under development, in Candida albicans lab strain SC5314. |
• | Most adaptors which survived from high concentrations of rezafungin remained susceptible to rezafungin. A few adaptors gained tolerance to rezafungin and cross-tolerance to other echinocandins drugs. |
• | The echinocandins-tolerant adaptors had diverse genome changes. Among the five types of aneuploidy found in these adaptors, segmental monosomy of chromosome R was predominant and was recurrently selected at different concentrations of rezafungin. |
Keywords : Aneuploidy, Paradoxical growth, Rezafungin, Candida albicans, Cross-tolerance
© 2022
Publié par Elsevier Masson SAS.
Vol 85 - N° 6
P. 702-769 - décembre 2022 Retour au numéro
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