Reduced T-cell response following a third dose of SARS-CoV-2 vaccine in infection-naïve people living with HIV - 29/11/22

Doi : 10.1016/j.jinf.2022.09.006

Majdouline El Moussaoui ^a,^{^{1
These authors contributed equally to this work.},}^⁎ , Salomé Desmecht ^b,^{^{1
These authors contributed equally to this work.}}, Aleksandr Tashkeev ^b, Nicolas Lambert ^c, Nathalie Maes ^d, Joachim Braghini ^a, Nicole Marechal ^a, Céline Quintana ^a, Karine Briquet ^a, Stéphanie Gofflot ^e, Françoise Toussaint ^f, Marie-Pierre Hayette ^f, Pieter Vermeersch ^g, Laurence Lutteri ^h, Céline Grégoire ⁱ, Yves Beguin ^e,ⁱ, Souad Rahmouni ^b, Michel Moutschen ^a, Daniel Desmecht ^j,^{^{1
These authors contributed equally to this work.}}, Gilles Darcis ^a,^{^{1
These authors contributed equally to this work.}}
^a Department of Infectious Diseases and General Internal Medicine, University Hospital of Liège, Avenue de l'Hôpital, 1, 4000 Liège, Belgium
^b Laboratory of Animal Genomics, GIGA-Medical Genomics. GIGA-Institute, University of Liege, Belgium
^c Department of Neurology, University Hospital of Liège, Belgium
^d Department of Biostatistics and Medico-Economic Information, University Hospital of Liège, Belgium
^e Department of Biothèque Hospitalo-Universitaire de Liège (BHUL), University Hospital of Liège, Belgium
^f Department of Clinical Microbiology, University Hospital of Liège, Belgium
^g Department of Laboratory Medicine, University Hospital of Leuven, Leuven, Belgium
^h Department of Clinical Chemistry, University Hospital of Liège, Belgium
ⁱ Department of Haematology, University Hospital of Liège, University of Liège, Belgium
^j Department of Animal Pathology, Fundamental and Applied Research for Animals and Health, University of Liège, Liège 4000, Belgium

^⁎Corresponding author.

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Highlights

•	People living with HIV show similar humoral immune responses towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals.
•	People living with HIV with no prior SARS-CoV-2 infection show reduced T-cell response towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals.
•	Hybrid immunity induces similar T-cell responses between people living with HIV and HIV-negative individuals.

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Keywords : SARS-CoV-2 mRNA vaccine, COVID-19 vaccine, Breakthrough infection, Antibody responses, Humoral, Cellular, Immune response, Neutralisation, Omicron, Third dose, People living with HIV, HIV

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Vol 85 - N° 6

P. 702-769 - décembre 2022 Retour au numéro

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Reduced T-cell response following a third dose of SARS-CoV-2 vaccine in infection-naïve people living with HIV - 29/11/22

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