Effectiveness of influenza vaccination in reducing influenza-like illness and related antibiotic prescriptions in adults from a primary care-based case-control study - 29/11/22
, Christopher Gianacas a, David J Muscatello a, Anthony T Newall a, Peter McIntyre b, Allen C Cheng c, d, e, Bette Liu aHighlights |
• | Influenza vaccination reduced primary care presentations for ILI. |
• | The pooled estimated reduction over 4 years was 24% (95%CI 11-34%). |
• | Influenza vaccination also reduced antibiotic prescribing for ILI. |
• | However, this was only observed in patients without comorbidities and aged 40-65yrs. |
Abstract |
Background |
Evidence on the effectiveness of influenza vaccine in preventing antibiotic prescriptions for influenza-like illness (ILI) in adults is limited.
Methods |
A primary care-based case-control study was conducted to estimate influenza vaccine effectiveness (VE) against influenza-like illness (ILI) and antibiotic prescribing for ILI in adults aged ≥40 years. Cases were patients diagnosed with ILI from 1st June to 30th September in each year, 2015-2018; a subset of those with ILI prescribed antibiotics was also defined. Controls were patients attending a practice who did not receive an ILI diagnosis. Generalised estimating equations were used to calculate adjusted VE overall, by age (<65 versus ≥65 years) and comorbidity status.
Results |
The number of ILI cases varied from 558 in 2018 to 2901 in 2017 and controls from 86618 in 2015 to 136763 in 2017. Over 4 years the pooled estimate of VE was 24% (95%CI, 11% to 34%) against ILI and 15% (95%CI, -3% to 29%) against antibiotic prescription for ILI. Influenza vaccine was effective in reducing ILI with an associated antibiotic prescriptions in patients aged <65 years (VE=23%, 95%CI, 3% to 38%) and if no comorbidities were recorded (VE=22%, 95%CI, 1% to 39%) but not in other subgroups.
Conclusions |
Influenza vaccine reduced the likelihood of antibiotic prescriptions for ILI in low-risk adults (40-64 years and those without comorbidities).
Le texte complet de cet article est disponible en PDF.Keywords : Influenza vaccination, Influenza-like illness, Influenza vaccine effectiveness, Adults, Comorbidities
Abbreviations : ILI, VE
Plan
Vol 85 - N° 6
P. 660-665 - décembre 2022 Retour au numéro
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