What are the prospects for durable immune control? - 20/11/22
Highlights |
• | Neutralizing antibodies block the virus-host interaction. |
• | The cellular response (CD4 and CD8 T-cells) controls viremia. |
• | Memory B cells are responsible for immunity after vaccination or infection. |
• | Heterogenicity in duration of the immunity induced by vaccines is significant. |
Abstract |
During the SARS CoV-2 primary infection, the neutralizing antibodies focused against the spike (S) glycoproteins are responsible for blockage of virus-host cell interaction. The cellular response mediated by CD4+ and CD8+ T-cells is responsible for control of viremia.
Immune memory against SARS-CoV-2 depends on virus type, replication kinetics and route of penetration. The formation and persistence of germinal centers are critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating durable immunity. They can persist up to 30 weeks after vaccination and several months after infection. Heterogeneity in the longevity of the vaccination-induced GC response is significant.
Le texte complet de cet article est disponible en PDF.Keywords : SARS CoV-2, Neutralizing antibodies, Immune control, Vaccine immunogenicity, Immune memory
Plan
Vol 52 - N° 8S
P. S4-S6 - novembre 2022 Retour au numéro
Article précédent
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