Basic Science of Autologous Orthobiologics : Part 1. Platelet-Rich Plasma - 18/11/22

Doi : 10.1016/j.pmr.2022.08.003

Peter A. Everts, PhD, FRSM ^a,^⁎ , Payman Sadeghi, MD ^b, David R. Smith, MD ^c
^a Gulf Coast Biologics, Research and Scientific Division, Fellow Royal Society of Medicine London, Fort Myers, FL, USA
^b National Headache Institute and National Stem Cell Clinic, Miami, FL, USA
^c Kingston Interventional Pain Medicine, Kingston Orthopaedic Pain Institute, Ontario, Canada

^∗Corresponding author. Veronica S. Shoemaker Boulevard, Suite 1, Fort Myers, FL 33916.Veronica S. Shoemaker Boulevard, Suite 1Fort MyersFL33916

Résumé

In recent years, autologous biological preparations have emerged as a growing area of medical innovation in interventional orthopedical procedures and surgical interventions. These cellular therapies are often referred to as orthobiologics and are derived from patient’s own tissues, such as blood, bone marrow, and adipose tissue to prepare platelet-rich plasma (PRP), bone marrow concentrate, and adipose tissue concentrate, respectively. In this article, we will emphasize and discuss the physiological variability of autologous PRP bioformulations regarding their effectivity in tissue repair. Furthermore, recent developments concerning platelet dosing, potentially effecting immunomodulation, and pain killing will be described.

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Keywords : Autologous orthobiologics, Platelet-rich plasma, Regenerative medicine, Platelets, Inflammation, Angiogenesis, Analgesic effects, Immunomodulation