Circulating levels of GDF-15 for predicting cardiovascular and cancer morbidity and mortality in type 2 diabetes: Findings from Da Qing IGT and Diabetes Study - 17/11/22
, Guangwei Li a, c, ⁎
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Highlights |
• | People with type 2 diabetes have metabolic disorders. |
• | If GDF-15 related to the risk of CVD and cancer in people with diabetes remains unclear. |
• | GDF-15 levels were related to increased risk of CVD and cancer morbidity and mortality. |
• | GDF-15 is a marker for the dual risk of CVD and cancer in people with diabetes. |
Abstract |
Aim |
To investigate the relationship between circulating growth differentiation factor (GDF-15) levels and the risk of cardiovascular disease and cancer in people with diabetes.
Methods |
Totally, 510 participants with type 2 diabetes were enrolled from the long-term follow-up of the Da Qing Impaired Glucose Tolerance (IGT) and Diabetes Study (2006–2009). Plasma GDF-15 levels were assessed. Outcomes of cardiovascular events, cancer, and related death were followed up until 2016.
Results |
Over a 7.5-year follow-up period, 143 (28.0%) of the participants died, and 155 and 56 experienced cardiovascular events and cancer respectively. Multivariable Cox analysis showed that higher circulating GDF-15 levels were significantly associated with the increased risk of cardiovascular and cancer death. The HRs after adjustment of traditional confounders were 1.90 (95%CI 1.31–2.74) and 2.50 (95%CI 1.34–4.67) respectively for an increase in one unit of loge transformed GDF-15 (pg/ml). The cause-specific hazard model analysis further confirmed the results after adjusting the same confounders. In addition, the higher GDF-15 levels were also significantly associated with the increased risk of cardiovascular events (HR=1.35, 95%CI: 1.04–1.76) and cancer (HR=1.62, 95%CI 1.06–2.47).
Conclusions |
Elevated circulating levels of GDF-15 predicted a significant increase in the dual risk of cancer and cardiovascular diseases in Chinese people with type 2 diabetes. Thus, it may be a potential predictor of these outcomes in people with diabetes.
Le texte complet de cet article est disponible en PDF.Keywords : GDF-15, Cardiovascular events, Cardiovascular death, Cancer, Cancer death
Abbreviations : GDF-15, HR, CI, SD, MACE, HbA1c, LDL-c, DM, SBP
Plan
Vol 48 - N° 6
Article 101380- novembre 2022 Retour au numéro
Article précédent
- Risk of sepsis and pneumonia in patients initiated on SGLT2 inhibitors and DPP-4 inhibitors
- Mei-Zhen Wu, Chanchal Chandramouli, Pui-Fai Wong, Yap-Hang Chan, Hang-Long Li, Si-Yeung Yu, Yi-Kei Tse, Qing-Wen Ren, Shuk-Yin Yu, Hung-Fat Tse, Carolyn S.P. Lam, Kai-Hang Yiu
- Prevalence and risk of diabetic complications in young-onset versus late-onset type 2 diabetes mellitus
- Yongin Cho, Hye-Sun Park, Byung Wook Huh, Seong Ha Seo, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, Young Ju Suh, So Hun Kim
Bienvenue sur EM-consulte, la référence des professionnels de santé.