A Glimpse of necroptosis and diseases - 15/11/22

Doi : 10.1016/j.biopha.2022.113925

Ming Yang ^a,^b, Wei Chen ^b, Liyu He ^b, Di Liu ^b, Li Zhao ^c, Xi Wang ^a,^d,^⁎
^a Department of Nutrition, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China
^b Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China
^c Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, Kunming, China
^d National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

^⁎Corresponding author at: Department of Nutrition, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.Department of Nutrition, Xiangya Hospital, Central South UniversityChangshaHunan410008China

Abstract

Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases. In this study, we reviewed the molecular mechanism underlying necroptosis, and discuss its role in the pathogenesis of various diseases. Finally, we summarize several current inhibitors of necroptosis and discuss the potential of targeting necroptosis as a therapeutic strategy for various diseases.

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Abbreviations : DAMPs, RIP1/3, TNF, RIPK1, TRADD, TRAF2, cIAP1, LUBAC, TAK1, TAB, NEMO, MLKL, mPTP, ROS, AKI, Nec-1, NOX4, DKD, ESRD, UCHL1, LN, p-STAT3, PBMCs, SLE, HCC, NAFLD, NASH, HFD, O-GlcNAc, PTS, IR, ALT, POCCLs, STAD, COPD, OPTN, ALS, AD

Keywords : Necroptosis, Programmed cell death, RIPK1, MLKL, Inflammation

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Introduction

The process of necroptosis

Necroptosis and diseases

Compounds and drugs that regulate necroptosis

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Vol 156

Article 113925- décembre 2022 Retour au numéro

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A Glimpse of necroptosis and diseases - 15/11/22

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