Tumour metabolism has gradually come to be regarded as a key target to prevent tumour growth and metastasis. The unique metabolic characteristics of tumours enable them to maintain self-proliferation in abnormal environments. In recent years, the necessity of hypoxia in the tumour microenvironment has been gradually recognized, and hypoxia-induced tumour metabolites are also regarded as key therapeutic targets. How these hypoxia-related metabolites support tumour development, how to regulate the malignant process of tumours, and how to prevent tumour immune escape have become urgent problems that need to be solved. In this review, we summarize the characteristic tumour regulation of hypoxia-related metabolites and the mechanisms that promote immune escape of tumours. Finally, we summarize the relevant targeted inhibitors in an attempt to provide some novel therapeutic insights.