Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulation - 15/11/22

Abstract |
Ginsenoside Rh2 (Rh2), the major bio-active ginsenoside that originated from the root of Panax ginseng, has become a “hot topic” for playing multifunctional roles in both tumor treatment and tumor microenvironment (TME) immunomodulation. Up to now, emerging experimental research about Rh2 in tumor therapy and immuno-regulation has been published, however, the specific reviews focused on its role in the TME were limited. Hence, in this article, we briefly summarized existing evidence supporting the anticancer effects and potential mechanisms of Rh2 according to the tumor type, including anti-proliferation, anti-invasion, and metastasis, induction of cell cycle arrest, anti-angiogenesis, promotion of reactive oxygen species and differentiation. Meanwhile, we shed light on the role of Rh2 in TME, with an emphasis on regulating tumor immunogenicity, immune cells, cytokines, and physicochemical properties of TME. Finally, the current research limitation and prospects of Rh2 were discussed.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Rh2 aids in killing tumor cells through numerous processes. |
• | Rh2 exerts anti-tumor activities by modulating important tumor related pathways. |
• | Rh2 plays important roles in regulating tumor microenvironment immunomodulation. |
• | More evidence-based experimental research and clinical trials on Rh2 are needed. |
Abbreviations : Rh2, TME, IL, TNF, ROS, NPC, BBB, NSCLC, m6A, STAT3, EMT, ALL, AML, PD-L1, CTX, IFN, NK, TAM, VEGF, NO, GFPL, ECG-MEs, TGF, HIF, PPP
Keywords : Ginsenoside, Tumor therapy, Tumor microenvironment
Plan
Vol 156
Article 113912- décembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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