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Development of precocious puberty in children: Surmised medicinal plant treatment - 15/11/22

Doi : 10.1016/j.biopha.2022.113907 
Xiao-Xu Han a, 1, , Fu-Ying Zhao b, 1 , Kan-Ru Gu a , Guo-Ping Wang c , Jing Zhang d , Rui Tao a, e , Jiao Yuan f , Jie Gu g, , Jian-Qiang Yu h, i,
a Department of Pharmacy, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
b Department of Gynecology, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
c Department of Reproductive Centre, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
d Department of Paediatric Endocrinology, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
e Department of Clinical Pharmacy, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
f Department of Neonatology, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
g Department of Paediatrics, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, China 
h Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China 
i Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan 750004, China 

Corresponding author.⁎⁎Corresponding author at: Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China.Department of Pharmacology, Ningxia Medical UniversityYinchuan750004China

Abstract

Precocious puberty in children is one of the common endocrine diseases in paediatrics. Epidemiological surveys have shown that the number of children with precocious puberty has significantly increased globally. Precocious puberty negatively affects the physical and mental health of children and may increase the risk of hypertension, diabetes, obesity and infertility in adulthood. Therefore, the initiating factors of adolescence have become core issues in the study of sexual development in children. Owing to developments in molecular genetics, many studies have been able to show that precocious puberty is mostly resulted in autosomal inheritance. For instance, makorin ring finger protein 3 gene (MKRN3) may be implicated in familial CPP. Gonadotropin-releasing hormone agonist (GnRHa) is the gold standard for treatment, but its safety still requires long-term evaluation and management. Traditional medicinal plants have been used in clinical treatments and in exploring novel treatment methods. From the collected datas, in Asia, traditional Chinese medicine treatment is based on the principles of nourishing Yin, lowering fire and draining fire from the liver to help precocious children and alleviate or delay the onset of precocious puberty by medicinal plants such as Anemarrhena asphodeloides Bge., Phellodendron amurense Rupr., Rehmannia glutinosa and Poria cocos Wolf. They play an important role in exploring the pharmacological mechanisms of precocious puberty treatment effects and drug development. Therefore, by elucidating the occurrence and development of precocious puberty, this review provides novel and valuable insights of paediatric endocrine therapy accessing the published researches on the effectiveness of traditional herbal medicine in the treatment of precocious puberty and its therapeutic mechanisms.

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Graphical Abstract




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Describing the occurrence of puberty and precocious puberty. The hormones (GnRH, LH, and FSH) in the fetus come from the mother. After being delivered, the hormone levels of LH and FSH from baby will reach a peak again due to feedback, but the level of GnRh was slowed. As children continually developing and growing, HPG axis is inhibited, and hormones gradually decrease until they are lost. Until 10 years old, GnRH is activated again to stimulate HPG axis to secrete hormones (E2, T) and promote the occurrence of puberty. However, precocious puberty is caused by different factors to induce puberty symptoms in children at a younger age ( particularly 8 years in girls and 9 years in boys). This brings with it a number of drawbacks and even some risks that can affect the development of children. Chinese herbal treatments have always had a long history of clinical research, and by following a large amount of literature it has been found that herbal treatments can be an effective treatment for precocious puberty, and are more popular than GnRha for their low price, as well as providing new ideas for the treatment of precocious puberty.


Describing the occurrence of puberty and precocious puberty. The hormones (GnRH, LH, and FSH) in the fetus come from the mother. After being delivered, the hormone levels of LH and FSH from baby will reach a peak again due to feedback, but the level of GnRh was slowed. As children continually developing and growing, HPG axis is inhibited, and hormones gradually decrease until they are lost. Until 10 years old, GnRH is activated again to stimulate HPG axis to secrete hormones (E2, T) and promote the occurrence of puberty. However, precocious puberty is caused by different factors to induce puberty symptoms in children at a younger age ( particularly 8 years in girls and 9 years in boys). This brings with it a number of drawbacks and even some risks that can affect the development of children. Chinese herbal treatments have always had a long history of clinical research, and by following a large amount of literature it has been found that herbal treatments can be an effective treatment for precocious puberty, and are more popular than GnRha for their low price, as well as providing new ideas for the treatment of precocious puberty.ga1

Le texte complet de cet article est disponible en PDF.

Highlights

From a multi-layered perspective, the occurrence and development of precocious puberty has been found to be closely related to the environment in which children grow, psychological changes and genetics.
Based on current research in the treatment of precocious puberty, GnRha has been found to have good therapeutic efficacy but still has some uncertainty.
Traditional medicinal plants have long term and stable clinical efficacy in treating precocious puberty, which could lay the foundation for the future development of medicines to treat.

Le texte complet de cet article est disponible en PDF.

Keywords : Precocious puberty, Adolescents, Chinese medicine traditional, Medicinal plants


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