The course of C-peptide levels in patients developing diabetes during anti-PD-1 therapy - 15/11/22
, Karlijn de Joode a, Tom J.J. Uyl a, Ronald van der Wal b, Marco W.J. Schreurs c, Sjoerd A.A. van den Berg b, d, Esther Oomen-de Hoop a, Cor H. van der Leest e, Layal Chaker b, Richard A. Feelders b, Astrid A.M. van der Veldt a, f, Arjen Joosse a, Stijn L.W. Koolen a, g, Joachim G.J.V. Aerts h, Ron H.J. Mathijssen a, Sander Bins aAbstract |
Introduction |
Immune checkpoint inhibitor (ICI) associated diabetes is a harmful adverse event (AE) in patients with cancer following anti-programmed (cell) death protein-1 (PD-1) treatment. There are no available biomarkers able to predict this AE. The primary aim of this study was to investigate C-peptide levels as potential predictor for the occurrence of ICI-related diabetes. The secondary aim was to describe the presence of islet autoantibodies and course of pancreatic enzymes in patients with and without ICI-related diabetes.
Methods |
From a total of 1318 patients with cancer who started anti-PD-1 treatment 8 cases and 16 controls were studied in this nested case-control study. C-peptide levels, islet autoantibodies, and pancreatic enzymes were measured in prospectively collected blood serum.
Results |
In cases versus controls, median C-peptide levels were comparable at baseline and before toxicity or at the corresponding time point in controls. No patient had C-peptide levels below reference range before toxicity onset. Two out of eight patients in the ICI-related diabetes group had positive islet autoantibodies, whereas one out of 16 patients in the control group had positive islet autoantibodies. Pancreatic enzymes were elevated before diabetes onset in one patient (13%) and in one control (6%) at the corresponding time point.
Conclusions |
In patients developing ICI-related diabetes, changes in C-peptide levels, islet autoantibody positivity, and pancreatic enzymes before ICI-related diabetes onset seem comparable to patients without ICI-related diabetes. (NTR: NL6828)
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Diabetes is a potentially life-threatening adverse event of ICI treatment. |
• | There was no decline in C-peptide levels prior to onset of ICI-related diabetes. |
• | Islet autoantibodies did not differ between ICI-related diabetes cases and controls. |
• | Pancreatic enzymes did not differ between ICI-related diabetes cases and controls. |
Keywords : Immunotherapy, Cancer treatment, C-peptide, Islet autoantibodies, Pancreatic enzymes
Plan
Vol 156
Article 113839- décembre 2022 Retour au numéro
Article précédent
- Traditional Chinese Medicine prescription Huang-Qi-Jian-Zhong-Tang ameliorates indomethacin-induced duodenal ulcers in rats by affecting NF-κB and STAT signaling pathways
- Houpan Song, Jingyue Qiu, Chang Yu, Meng Xiong, Chen Ou, Baoping Ren, Meiqi Zhong, Meiyan Zeng, Qinghua Peng
- Reversal of multidrug resistance by Fissistigma latifolium–derived chalconoid 2-hydroxy-4,5,6-trimethoxydihydrochalcone in cancer cell lines overexpressing human P-glycoprotein
- Yu-Ning Teng, Chin-Chuan Hung, Pei-Heng Kao, Ying-Tzu Chang, Yu-Hsuan Lan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?