Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis - 12/11/22
Doi : 10.1016/j.jpeds.2022.07.033
Nicole S. Glaser, MD 1, ⁎ 
, Kimberly S. Quayle, MD 2, Julie K. McManemy, MD, MPH 3, Lise E. Nigrovic, MD, MPH 4, Leah Tzimenatos, MD 5, Michael J. Stoner, MD 6, Jonathan E. Bennett, MD 7, Jennifer L. Trainor, MD 8, Arleta Rewers, MD, PhD 9, Jeff E. Schunk, MD 10, Sage R. Myers, MD 11, Maria Y. Kwok, MD, MPH 12, Kathleen M. Brown, MD 13, Simona Ghetti, PhD 14, T. Charles Casper, PhD 10, Cody S. Olsen, MS 10, Nathan Kuppermann, MD, MPH 1, 5
for the
, Kimberly S. Quayle, MD 2, Julie K. McManemy, MD, MPH 3, Lise E. Nigrovic, MD, MPH 4, Leah Tzimenatos, MD 5, Michael J. Stoner, MD 6, Jonathan E. Bennett, MD 7, Jennifer L. Trainor, MD 8, Arleta Rewers, MD, PhD 9, Jeff E. Schunk, MD 10, Sage R. Myers, MD 11, Maria Y. Kwok, MD, MPH 12, Kathleen M. Brown, MD 13, Simona Ghetti, PhD 14, T. Charles Casper, PhD 10, Cody S. Olsen, MS 10, Nathan Kuppermann, MD, MPH 1, 5for the
Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group∗
1 Department of Pediatrics, University of California Davis Health, University of California Davis School of Medicine, CA
2 Division of Emergency Medicine, Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine in St. Louis, St Louis, MO
3 Division of Emergency Medicine, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX
4 Division of Emergency Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA
5 Department of Emergency Medicine, University of California Davis Health, University of California Davis School of Medicine, Sacramento, CA
6 Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University School of Medicine, Columbus, OH
7 Division of Emergency Medicine, Nemours/AI DuPont Hospital for Children, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA
8 Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL
9 Division of Emergency Medicine, Department of Pediatrics, The Colorado Children's Hospital, University of Colorado-Denver School of Medicine, Aurora, CO
10 Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
11 Division of Emergency Medicine, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
12 Division of Emergency Medicine, Department of Pediatrics, New York Presbyterian Morgan Stanley Children's Hospital, Columbia University College of Physicians and Surgeons, New York, NY
13 Division of Emergency Medicine, Department of Pediatrics, Children's National Medical Center, The George Washington School of Medicine and Health Sciences, Washington, DC
14 Department of Psychology, University of California Davis, Sacramento, CA
∗Reprint requests: Nicole S. Glaser, MD, Department of Pediatrics, University of California Davis School of Medicine, 2516 Stockton Blvd, Sacramento, CA 95817Department of PediatricsUniversity of California Davis School of Medicine2516 Stockton BlvdSacramentoCA95817
Abstract |
Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.
Le texte complet de cet article est disponible en PDF.Abbreviations : BUN, DKA, ED, FLUID, GCS, IL, PECARN
Plan
| Supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Grant U01 HD062417) and the Emergency Medical Services for Children Network Development Demonstration Program of the Maternal and Child Health Bureau, Health Resources and Services Administration, under cooperative agreement (Awards U03 MC00008, U03 MC00001, U03 MC00003, U03 MC00006, U03 MC00007, U03 MC22684, and U03 MC22685). The content and conclusions of this article are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by the Health Resources and Services Administration, the Department of Health and Human Services, or the US government. The authors declare no conflicts of interest. |
© 2022
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 250
P. 100-104 - novembre 2022 Retour au numéro
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