Molecular exploration of hidden pleiotropic activities of azoles on dermatophytes in human tinea corporis infection - 12/11/22
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Highlights |
• | Dermatophyte infections are widespread worldwide and are the most prevalent cause of fungal infection. |
• | The disease may be acquired through person-to-person transmission, typically by an infected individual. |
• | This review illustrates the hidden pleiotropic activity of azoles on dermatophytes in human tinea corporis infection. |
Abstract |
Dermatophyte infections are widespread worldwide and are the most prevalent cause of fungal infection of the skin, hair, and nails. Tinea corporis is most commonly caused by dermatophytes belonging to three genera: Trichophyton , Microsporum , and Epidermophyton. The disease may be acquired through person-to-person transmission, typically by direct communication with an infected individual. Since dermatophytes causing tinea corporis infection are restricted to superficial keratinized tissue, topical treatments are most effective in patients with naïve tinea corporis unless the disease is widespread. Dermatophyte adherence to a keratinized structure is an essential step in dermatophytosis pathogenesis, whereby proteolytic enzyme activity is converted into a particular keratolytic activity that encourages the dermatophyte to use keratin as the sole source of carbon. Despite increasing dermatophytosis worldwide, particularly in the tropics, this research has often been neglected, appears to predominate globally, and presents practitioners with a therapeutic challenge. However, experts supported the use of allylamines in the pleiotropic molecular exploration of azoles, including reactive oxygen species (ROS) inducer, anti-inflammatory, antibacterial, and wide-spectrum antimycotic effects. Therefore, the current review aims to update and reform this essential subject and illustrate the recent advancement of the hidden pleiotropic activity of azoles at the molecular level on dermatophytes in human tinea corporis infection.
Le texte complet de cet article est disponible en PDF.Keywords : Ketoconazole, Tinea corporis, Dermatophytes, Anti-inflammatory, Reactive oxygen species
Plan
Vol 32 - N° 4
Article 101311- novembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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