Monoclonal antibody therapies against SARS-CoV-2 - 27/10/22
Doi : 10.1016/S1473-3099(22)00311-5
Daniele Focosi, PhD a, Scott McConnell, PhD c, Arturo Casadevall, ProfPhD c, Emiliano Cappello, PhD b, d, Giulia Valdiserra, PharmD b, d, Marco Tuccori, PhD d, ⁎ 
a North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy
b Unit of Adverse Drug Reactions Monitoring, Pisa University Hospital, Pisa, Italy
c Department of Medicine, Johns Hopkins School of Public Health and School of Medicine, Baltimore, MD, USA
d Unit of Pharmacology and Pharmacovigilance, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
* Correspondence to: Dr Marco Tuccori, Unit of Adverse Drug Reactions Monitoring, Pisa University Hospital, Pisa 56126, Italy Unit of Adverse Drug Reactions Monitoring Pisa University Hospital Pisa 56126 Italy
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Summary |
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs and their effect as therapeutics in the pandemic, including structural classification, outcomes in clinical trials that led to the authorisation of mAbs, and baseline and treatment-emergent immune escape. We show how the omicron (B.1.1.529) variant of concern has reset treatment strategies so far, discuss future developments that could lead to improved outcomes, and report the intrinsic limitations of using mAbs as therapeutic agents.
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© 2022
Elsevier Ltd. Tous droits réservés.
Vol 22 - N° 11
P. e311-e326 - novembre 2022 Retour au numéro
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