Patch testing with glucosides: The North American Contact Dermatitis Group experience, 2009-2018 - 14/10/22
Abstract |
Background |
Alkyl glucosides are nonionic surfactants that are increasingly used in personal care products.
Objective |
To characterize positive patch test reactions to decyl glucoside (5% petrolatum, tested 2009-2018) and lauryl glucoside (3% petrolatum, tested 2017-2018).
Methods |
Retrospective analysis of patients tested by the North American Contact Dermatitis Group.
Results |
Of 24,097 patients patch tested to decyl and/or lauryl glucoside, 470 (2.0%) had positive reactions. Compared with glucoside-negative patients, glucoside-positive patients had higher odds of occupational skin disease (13.4% vs 10.1%; P = .0207), history of hay fever (38.5% vs 31.6%; P = .0014), atopic dermatitis (39.0% vs 28.6%; P < .0001), and/or asthma (21.8% vs 16.5%; P = .0023). Most glucoside reactions (83.9%) were currently relevant. The most common source was personal care products (63.0%), especially hair products (16.5%) and skin cleansers (15.2%). Of 4933 patients tested to decyl and lauryl glucoside, 134 (2.7%) were positive to 1 or both; 43.4% (43 of 99) of decyl-positive patients were also positive to lauryl glucoside and 55.1% (43/78) of lauryl glucoside patients were also positive to decyl glucoside.
Limitations |
The cohort predominantly reflects a referral population, and follow-up after testing was not captured.
Conclusion |
Glucoside positivity occurred in 2.0% of the tested patients. Reactions were often clinically relevant and linked to personal care products. Cross-reactivity was >40%.
Le texte complet de cet article est disponible en PDF.Key words : allergic contact dermatitis, contact allergy, decyl glucoside, glucoside, lauryl glucoside, patch test
Abbreviations used : CAMP, NACDG, OR, PCP
Plan
Funding sources: Supported by resources and use of facilities at Park Nicollet/Health Partners. |
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IRB approval status: Approved by the Health Partners institutional review board. |
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Reprints not available from the authors. |
Vol 87 - N° 5
P. 1033-1041 - novembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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