Patch testing with glucosides: The North American Contact Dermatitis Group experience, 2009-2018 - 14/10/22
, Amber R. Atwater, MD e, Joel G. DeKoven, MD, MHSc f, Melanie D. Pratt, MD g, Howard I. Maibach, MD h, James S. Taylor, MD i, Donald V. Belsito, MD j, Jonathan I. Silverberg, MD, PhD k, Margo J. Reeder, MD l, Kathryn A. Zug, MD m, Denis Sasseville, MD n, Joseph F. Fowler, MD o, Vincent A. DeLeo, MD p, Marie-Claude Houle, MD q, Cory A. Dunnick, MD rAbstract |
Background |
Alkyl glucosides are nonionic surfactants that are increasingly used in personal care products.
Objective |
To characterize positive patch test reactions to decyl glucoside (5% petrolatum, tested 2009-2018) and lauryl glucoside (3% petrolatum, tested 2017-2018).
Methods |
Retrospective analysis of patients tested by the North American Contact Dermatitis Group.
Results |
Of 24,097 patients patch tested to decyl and/or lauryl glucoside, 470 (2.0%) had positive reactions. Compared with glucoside-negative patients, glucoside-positive patients had higher odds of occupational skin disease (13.4% vs 10.1%; P = .0207), history of hay fever (38.5% vs 31.6%; P = .0014), atopic dermatitis (39.0% vs 28.6%; P < .0001), and/or asthma (21.8% vs 16.5%; P = .0023). Most glucoside reactions (83.9%) were currently relevant. The most common source was personal care products (63.0%), especially hair products (16.5%) and skin cleansers (15.2%). Of 4933 patients tested to decyl and lauryl glucoside, 134 (2.7%) were positive to 1 or both; 43.4% (43 of 99) of decyl-positive patients were also positive to lauryl glucoside and 55.1% (43/78) of lauryl glucoside patients were also positive to decyl glucoside.
Limitations |
The cohort predominantly reflects a referral population, and follow-up after testing was not captured.
Conclusion |
Glucoside positivity occurred in 2.0% of the tested patients. Reactions were often clinically relevant and linked to personal care products. Cross-reactivity was >40%.
Le texte complet de cet article est disponible en PDF.Key words : allergic contact dermatitis, contact allergy, decyl glucoside, glucoside, lauryl glucoside, patch test
Abbreviations used : CAMP, NACDG, OR, PCP
Plan
| Funding sources: Supported by resources and use of facilities at Park Nicollet/Health Partners. |
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| IRB approval status: Approved by the Health Partners institutional review board. |
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| Reprints not available from the authors. |
Vol 87 - N° 5
P. 1033-1041 - novembre 2022 Retour au numéro
Article précédent
- Medical adhesive allergens: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2018
- Amber Reck Atwater, Raina Bembry, Beiyu Liu, Erin M. Warshaw, Joel G. DeKoven, Jonathan I. Silverberg, James S. Taylor, Kathryn A. Zug, Marie-Claude Houle, Donald V. Belsito, Howard I. Maibach, Margo J. Reeder, Denis Sasseville, Cory Dunnick, Joseph F. Fowler, Melanie D. Pratt, Vincent A. DeLeo
- The immediate patch test reaction to fragrance in patients with allergic contact dermatitis to fragrance: A prospective study
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