Hand eczema and temporal variation of Staphylococcus aureus clonal complexes: A prospective observational study - 14/10/22
Abstract |
Background |
Hand eczema (HE) is frequently associated with Staphylococcus aureus; however, its role in the pathogenesis of HE is poorly understood.
Objective |
To investigate the temporal variation in S aureus subtypes, ie, clonal complex (CC) types, on the hands and relate it to S aureus colonization in the nose and severity in a cohort of HE patients.
Methods |
S aureus from the hands and nose of 50 adult HE patients and 50 controls was prospectively identified at 5 visits over 3 weeks.
Results |
S aureus was identified on the hands of 23 (46%) patients at 2 or more visits and on the hands of 1 control once. Of the HE patients with S aureus colonization, 78% had the same S aureus CC type over time. Twenty-one patients had the same S aureus CC type on the hands and in the nose. Persistent colonization was strongly related to an increased disease severity.
Limitations |
A relatively small S aureus culture-positive population.
Conclusion |
The temporal stability of S aureus CC type and high occurrence of the identical subtypes on the hands and in the nose imply that S aureus colonization in patients with HE is of a more permanent nature. Taken together with the finding that persistent colonization and HE severity are clearly related, our results indicate that S aureus may contribute to the perpetuating course of HE.
Le texte complet de cet article est disponible en PDF.Key words : carrier pattern, carrier state, clonal complex, hand eczema, HECSI, spa, Staphylococcus aureus
Abbreviations used : AD, CC, FLG, HE, HECSI, LS, NLS, S aureus, SD, Spa
Plan
Funding sources: Grants from The Danish Working Environment Research Fund (20185100823), Augustinusfonden, Aage Bangs Fund. |
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IRB approval status: Approved by the local science ethics committee, Denmark (approval no. H-18049625) and the Danish Data Protection Agency (approval no. VD-2019-15). |
Vol 87 - N° 5
P. 1006-1013 - novembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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