Diagnostic value of serum KL-6 and IL-6 levels in critically ill patients with COVID-19-associated pneumonia - 13/10/22
Doi : 10.1016/j.jinf.2022.08.016
Si-Ho Kim a, 1, Hyun Kyu Cho b, 1, Chun-Hoo Jeon a, Hye Sung Ock b, Beomsu Shin b, ⁎ 
, Yu Mi Wi a, ⁎
, Yu Mi Wi a, ⁎ a Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon-si 51353, Republic of Korea
b Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Republic of Korea
⁎Corresponding author at: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine (Beomsu Shin); Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine (Yu Mi Wi).Division of Pulmonary and Critical Care MedicineDepartment of MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineRepublic of Korea
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Highlights |
• | The role of KL-6 and IL-6 for predicting mortality in critically ill COVID-19 patients was studied. |
• | Peak KL-6 and IL-6 levels were elevated in deceased COVID-19 patients. |
• | In multivariable analysis, peak KL-6 ≥ 1019.2 U/mL was associated with mortality. |
• | Increase in KL-6 level 1 week after admission was significantly higher in the deceased group. |
• | Serum KL-6 and IL-6 levels could predict mortality in critically ill COVID-19 patients. |
Keyword : COVID-19, SARS-CoV-2, Krebs von den lungen-6, Interleukin-6, Mortality
Plan
© 2022
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 85 - N° 5
P. 573-607 - novembre 2022 Retour au numéro
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