Remdesivir modifies interferon response in hospitalized COVID-19 patients - 13/10/22
Doi : 10.1016/j.jinf.2022.07.021
Sarah L. Murphy a, b, Bente Halvorsen a, b, Andreas Barratt-Due d, e, Anne Ma Dyrhol-Riise a, f, Pål Aukrust a, b, c, Marius Trøseid a, b, c, Tuva B. Dahl a, d, 1, ⁎ 
a Institute of Clinical Medicine, University of Oslo, Oslo 0318, Norway
b Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway
c Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway
d Division of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway
e Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
f Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway
⁎Corresponding author at: Institute of Clinical Medicine, University of Oslo, Oslo 0318, Norway.Institute of Clinical MedicineUniversity of OsloOslo0318Norway
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Highlights |
• | Remdesivir downregulates interferon responses in hospitalized COVID-19 patients. |
• | Treatment had a particularly strong effect on interferon γ. |
• | This response could be beneficial in mild, but not in severe disease. |
• | Treatment options in COVID-19 could differ according to disease severity. |
Plan
© 2022
Publié par Elsevier Masson SAS.
Vol 85 - N° 5
P. 573-607 - novembre 2022 Retour au numéro
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