A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital - 13/10/22
, Sara Lear 1, Laura Watson 3, Ashley Shaw 1, Mark Ferris 1, Rainer Doffinger 1, Rachel Bousfield 1, Katherine Sharrocks 1, Michael P. Weekes 1, Ben Warne 1, Dominic Sparkes 1, 4, Nick K Jones 1, 4, Lucy Rivett 1, 4, Matthew Routledge 1, 4, Afzal Chaudhry 1, Katherine Dempsey 3, Montgomery Matson 5, Adil Lakha 5, George Gathercole 5, Olivia O'Connor 5, Emily Wilson 5, Orthi Shahzad 5, Kieran Toms 5, Rachel Thompson 5, Ian Halsall 1, David Halsall 1, Sally Houghton 1, Sofia Papadia 6, 7, Nathalie Kingston 6, 8, Kathleen E Stirrups 6, 8, Barbara Graves 6, 7, Paul Townsend 6, Neil Walker 6, 8, Hannah Stark 6, 7, the CITIID-NIHR BioResource COVID-19 Collaboration
Daniela De Angelis 9, Shaun Seaman 9, Gordon Dougan 10, 11, John R Bradley 1, 6, M. Estée Török 1, 10, Ian Goodfellow 12, †, Stephen Baker 10, 11, †
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Highlights |
• | The risk of SARS-CoV-2 infection in healthcare workers is highly heterogeneous |
• | The risk of SARS-CoV-2 is significantly higher in BAME healthcare workers |
• | Working in COVID-19 specific areas increases the risk of infection |
• | Porters, domestic staff, and healthcare assistants are healthcare staff at highest risk of SARS-CoV-2 infection. |
Abstract |
Objectives |
To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs).
Methods |
We conducted a prospective sero-epidemiological study of HCWs at a major UK teaching hospital using a SARS-CoV-2 immunoassay. Risk factors for seropositivity were analysed using multivariate logistic regression.
Results |
410/5,698 (7·2%) staff tested positive for SARS-CoV-2 antibodies. Seroprevalence was higher in those working in designated COVID-19 areas compared with other areas (9·47% versus 6·16%) Healthcare assistants (aOR 2·06 [95%CI 1·14-3·71]; p=0·016) and domestic and portering staff (aOR 3·45 [95% CI 1·07-11·42]; p=0·039) had significantly higher seroprevalence than other staff groups after adjusting for age, sex, ethnicity and COVID-19 working location. Staff working in acute medicine and medical sub-specialities were also at higher risk (aOR 2·07 [95% CI 1·31-3·25]; p<0·002). Staff from Black, Asian and minority ethnic (BAME) backgrounds had an aOR of 1·65 (95% CI 1·32 – 2·07; p<0·001) compared to white staff; this increased risk was independent of COVID-19 area working. The only symptoms significantly associated with seropositivity in a multivariable model were loss of sense of taste or smell, fever, and myalgia; 31% of staff testing positive reported no prior symptoms.
Conclusions |
Risk of SARS-CoV-2 infection amongst HCWs is highly heterogeneous and influenced by COVID-19 working location, role, age and ethnicity. Increased risk amongst BAME staff cannot be accounted for solely by occupational factors.
Le texte complet de cet article est disponible en PDF.Key words : SARS-CoV-2, COVID-19, sero-epidemiology, healthcare workers, risk factor analysis
Plan
Vol 85 - N° 5
P. 557-564 - novembre 2022 Retour au numéro
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