Effectiveness of pulmonary rehabilitation in individuals with Chronic Obstructive Pulmonary Disease according to inhaled therapy: The Maugeri study - 23/09/22
, Mara Paneroni a, Antonio Spanevello b, c, Piero Ceriana d, Bruno Balbi e, Beatrice Salvi a, Nicolino Ambrosino fAbstract |
Background and aim |
Real-life studies report discordant prescribing of inhaled triple therapy (TT) among individuals with COPD. Guidelines recommend pulmonary rehabilitation (PR) for persistent breathlessness and/or exercise limitation. This real-life study aimed to assess the effects of in-patient PR in individuals under TT as compared to other inhaled therapies (no TT).
Methods |
Multicentric, retrospective analysis of data from individuals admitted to in-hospital PR. Baseline characteristics were recorded and lung function was assessed. Outcome measures were: 6-min walking test (6MWT: primary outcome), Medical Research Council (MRC) scale for dyspnoea, and COPD assessment test (CAT).
Results |
Data of pre and post program 6MWT of 1139 individuals were available. Pulmonary rehabilitation resulted in significant improvement in 6MWT in both groups, however, the effect size (by 54.3 ± 69.7 vs 42.5 ± 64.2 m, p = 0.004) and proportion of individuals reaching the minimal clinically important difference (MCID) of 6MWT (64.2%, vs 54.3%, p = 0.001) were higher in TT group. Both groups significantly improved also the other outcome measures. The significant independent predictors of reaching the MCID of 6MWT were hospital provenience, TT use, and high eosinophils count.
Conclusion |
Pulmonary rehabilitation results in significant benefits in individuals with COPD irrespective of the use of TT. However, individuals under TT report larger benefits in exercise tolerance than those under no TT.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Effects of pulmonary rehabilitation in COPD under inhaled triple therapy (TT) as compared to individuals not using TT are unclear. |
• | Significant post program improvements in 6MWT were found in both groups. |
• | Effect size and % of individuals reaching the MCID of 6MWT were higher in TT group. |
• | Independent predictors for MCID of 6MWT were hospital provenience, TT use, and high eosinophils count. |
Keywords : COPD triple therapy, Airflow limitation, Exercise training, Exercise capacity, Dyspnoea, CAT, Inhaled steroids, Bronchodilators
Plan
Vol 202
Article 106967- octobre 2022 Retour au numéro
Article précédent
- Glittre endurance test: A new test to assess the functional capacity of individuals with chronic obstructive pulmonary disease
- Liliane Patrícia de Souza Mendes, Verônica Franco Parreira, Lissa M. Spencer, Bill Zafiropoulos, Bianca Carmona Rocha, Zoe J. McKeough, Marcelo Velloso, Jennifer A. Alison
- Luminal mucus plugs are spatially associated with airway wall thickening in severe COPD and asthma: A single-centered, retrospective, observational study
- Cecilia Tran, Gaurav Veer Singh, Ehsan Haider, Colm Boylan, Carmen Venegas, Shaista Riaz, Suad Al Duwaiki, Moustafa Yehia, Terence Ho, Parameswaran Nair, Sarah Svenningsen, Miranda Kirby
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?