To determine which combination of imaging modalities/contrast, radiomics models, and how many features provides the best diagnostic performance for the differentiation between low- and high-grade soft tissue sarcomas (STS) using a radiomics approach.

MRI and CT from 39 patients with a histologically confirmed STS were prospectively analyzed. Images were evaluated both quantitatively by radiomics models and qualitatively by visual evaluation (used as reference) for grading (low-grade vs high-grade). In radiomics analysis, 120 radiomic features were extracted and contributed into three models: least absolute shrinkage and selection operator with logistic regression(LASSO-LR), recursive feature elimination and cross-validation (RFECV-SVC) and analysis of variance with SVC (ANOVA-SVC). Those were applied to different combinations of imaging modalities acquisition, with and without contrast medium administration, as well as selected number of features.

Fat-saturated T2w (FS-T2w) MR images using RFECV-SVC radiomic models involving five features yielded the best results with mean sensitivity, specificity, and accuracy of 92% ± 10%, 78% ± 30%, and 89% ± 12%, respectively. The performance of radiomics was better than that of conventional analysis (67% accuracy) for STS grading. Combination of multiple contrast or imaging modalities did not increase the diagnostic performance.

FS-T2w MR images alone with a five-feature radiomics analysis usingh REFCV-SVC model may be able to provide sufficient diagnositic performance compared to conventional visual evaluation with multiple MRI contrast and CT imaging.