Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability - 10/09/22
, Vesna Jaćević b, c , Zoran Miloradović a , Sladjan D. Milanović d , Djurdjica Jovović a , Milan Ivanov a , Danijela Karanović a , Una-Jovana Vajić a , Nevena Mihailović-Stanojević a Objective |
Background |
The main cause of death among patients with malignant hypertension is a kidney failure. The promising field in essential and malignant hypertension therapy could be centered on the amelioration of oxidative stress using antioxidant molecules like resveratrol. Resveratrol is a potent antioxidative agent naturally occurred in many plants that possess health-promoting properties.
Methods |
In the present study, we investigated the therapeutic potential of resveratrol, a polyphenol with anti-oxidative activity, in NG-L-Arginine Methyl Ester (L-NAME) treated spontaneously hypertensive rats (SHR) - malignantly hypertensive rats (MHR).
Results |
Resveratrol significantly improves oxidative damages by modulation of antioxidant enzymes and suppression of prooxidant factors in the kidney tissue of MHR. Enhanced antioxidant defense in the kidney improves renal function and ameliorates the morphological changes in this target organ. Besides, protective properties of resveratrol are followed by the restoration of the nitrogen oxide (NO) pathway. 4) Conclusion: Antioxidant therapy with resveratrol could represent promising therapeutical approach in hypertension, especially malignant, against kidney damage.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Resveratrol attenuates kidney damage in malignantly hypertensive rats. |
• | Renoprotection of resveratrol is associated with a blood pressure lowering. |
• | Resveratrol increases glomerular filtration while decreases proteinuria. |
• | Endogenous antioxidant defense of the malignantly hypertensive rats is enhanced after resveratrol treatment. |
• | Resveratrol decreases overproduction of inflammatory 3-NT leading to renal tubular protection in this model. |
Abbreviations : NCDs, CVD, CKD, ROS, RNS, SAP, DAP, SHR, L-NAME, IMR, SHR+R, MHR, MHR+R, Up, Cr, MDA, AOPP, O2.−, SOD, PON1, PAB, TOS, TAC, OSI, PAS, RDS
Keywords : Kidney, L-NAME, Nitrotyrosine, Oxidative stress, Resveratrol, Spontaneously and malignant hypertension
Plan
Vol 154
Article 113642- octobre 2022 Retour au numéro
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