Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases - 10/09/22

Doi : 10.1016/j.biopha.2022.113626

Jiami Zou ^a,^{^{1
These authors contributed equally}}, Jiaojiao Wang ^a,^b,^{^{1
These authors contributed equally}}, Weile Ye ^a, Jing Lu ^c,^d, Chengzhi Li ^e, Dongmei Zhang ^a, Wencai Ye ^a, Suowen Xu ^f,^{^{2
https://orcid.org/0000-0002-5488-5217}}, Chunbo Chen ^b, Peiqing Liu ^c,^d,^⁎,^{^{3
https://orcid.org/0000-0003-4388-2173}} , Zhiping Liu ^a,^⁎,^{^{4
https://orcid.org/0000-0001-7272-6917}}
^a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, 511436 Guangzhou, China
^b Department of Critical Care Medicine, Maoming People’s Hospital, Maoming, 525000 Guangdong, China
^c National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
^d Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
^e Department of Interventional Radiology and Vascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China
^f Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

^⁎Correspondence to: School of Pharmaceutical Sciences, Sun Yat-sen University, Higher Education Mega Center, Guangzhou 510006, China.School of Pharmaceutical Sciences, Sun Yat-sen University, Higher Education Mega CenterGuangzhou510006China^⁎⁎Correspondence to: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, No. 855, East Xingye Avenue, 511436 Guangzhou, China.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan UniversityNo. 855, East Xingye AvenueGuangzhou511436China

Abstract

Citri Reticulatae Pericarpium (CRP) has been utilized as a versatile medicinal herb with wide cardiovascular benefits in Asian nations for centuries. Accumulating evidence suggests that CRP and its components are effective in preventing cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, myocardial ischemia, arrhythmia, cardiac hypertrophy, heart failure, and hypertension. Studies show that the two most bioactive components of CRP are flavonoids and volatile oils. The cardiovascular protective effects of CRP have attracted considerable research interest due to its hypolipidemic, antiplatelet activity, antioxidant and anti-inflammatory effects. Hereby, we provide a rigorous and up-to-date overview of the cardiovascular protective properties and the potential molecular targets of CRP, and finally highlight the pharmacokinetics and the therapeutic potential of the main pharmacologically active components of CRP to treat CVDs.

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Highlights

•	Outlined the main bioactive components of Citri Reticulatae Pericarpium (CRP).
•	Summarized the bioavailability of CRP’s main active ingredients.
•	Elucidated the cardiovascular therapeutic effects of CRP.
•	Illustrated the molecular targets of CRP in cardiovascular disease treatment.
•	Exploited the therapeutic potential of CRP in treating cardiovascular diseases.

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Keywords : Citri Reticulatae Pericarpium, Chenpi, Physiologically active compounds, Citrus flavonoids, Cardiovascular diseases

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Article 113626- octobre 2022 Retour au numéro

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Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases - 10/09/22

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