The emerging role of noncoding RNAs in the Hedgehog signaling pathway in cancer - 10/09/22
Abstract |
Hedgehog (HH), a conserved signaling pathway, is involved in embryo development, organogenesis, and other biological functions. Dysregulation and abnormal activation of HH are involved in tumorigenesis and tumor progression. With the emergence of interest in noncoding RNAs, studies on their involvement in abnormal regulation of biological processes in tumors have been published one after another. In this review, we focus on the crosstalk between noncoding RNAs and the HH pathway in tumors and elaborate the mechanisms by which long noncoding RNAs and microRNAs regulate or are regulated by HH signaling in cancer. We also discuss the interaction between noncoding RNAs and the HH pathway from the perspective of cancer hallmarks, presenting this complex network as concisely as possible and organizing ideas for cancer diagnosis and treatment.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Figure 1: The emerging role of noncoding RNAs in the Hedgehog signaling pathway in cancer
Highlights |
• | Noncoding RNAs act on the HH signal pathway that acts classically or nonclassically. |
• | NcRNAs act on HH ligand, receptor, and nuclear factors or as its downstream target. |
• | Cancer hallmarks can explain the interaction between lncRNA or miRNA and HH pathway in cancer. |
• | Tumor biological markers and antitumor-targeted drugs can target lncRNA or miRNA via the HH signaling pathway. |
Abbreviations : HH, PTCH, SMO, SHH, DHH, IHH, TNM, HCC, LUAD/LADC, AR, RCC, HSC, NSCLC, NPC, PDAC, MB, CML, BCC, CCA, RB, MM, VEGFA, PDGFA, HUVECs, TGF-β, EMT, ECAR, PARP, CAF, CSCC, BMSCs, CRPC
Keywords : Hedgehog, LncRNA, MiRNA, Cancer hallmarks, Molecular mechanisms
Plan
Vol 154
Article 113581- octobre 2022 Retour au numéro
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