Pharmacological effects and mechanisms of tannic acid - 10/09/22
Abstract |
In recent years, increasing attention has been paid to the pharmacological efficacy of tannins. Tannic acid (TA), the simplest hydrolysable tannin that has been approved by the FDA as a safe food additive, is one of the most important components of these traditional medicines. Studies have shown that TA displays a wide range of pharmacological activities, such as anti-inflammatory, neuroprotective, antitumor, cardioprotective, and anti-pathogenic effects. Here, we summarize the known pharmacological effects and associated mechanisms of TA. We focus on the effect and mechanism of TA in various animal models of inflammatory disease and organ, brain, and cardiovascular injury. Moreover, we discuss the possible molecular targets and signaling pathways of TA, in addition to the pharmacological effects of TA-based nanoparticles and TA in combination with chemotherapeutic drugs.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The pharmacological effects of TA are largely a result of its powerful antioxidant and anti-inflammatory activity. |
• | TA can regulate multiple signaling pathways through several targets, including TGF-β, EGFR, and bFGF. |
• | TA can be combined with chemotherapeutic agents to produce synergistic anticancer effects. |
• | TA presents effective activity against several bacteria and viruses. |
Keywords : Tannic acid, Pharmacological efficacy, Anti-inflammatory, Neuroprotective, Antitumor, Cardioprotective
Plan
Vol 154
Article 113561- octobre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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