Dermatoscopic and clinical features of congenital or congenital-type nail matrix nevi: A multicenter prospective cohort study by the International Dermoscopy Society - 19/08/22
Abstract |
Background |
Congenital nail matrix nevi (NMN) are difficult to diagnose because they feature clinical characteristics suggestive of adult subungual melanoma. Nail matrix biopsy is difficult to perform, especially in children.
Objective |
To describe the initial clinical and dermatoscopic features of NMN appearing at birth (congenital) or after birth but before the age of 5 years (congenital-type).
Methods |
We conducted a prospective, international, and consecutive data collection in 102 hospitals or private medical offices across 30 countries from 2009 to 2019.
Results |
There were 69 congenital and 161 congenital-type NMNs. Congenital and congenital-type NMN predominantly displayed an irregular pattern of longitudinal microlines (n = 146, 64%), reminiscent of subungual melanoma in adults. The distal fibrillar (“brush-like”) pattern, present in 63 patients (27.8%), was more frequently encountered in congenital NMN than in congenital-type NMN (P = .012). Moreover, congenital NMN more frequently displayed a periungual pigmentation (P = .029) and Hutchinson’s sign (P = .027) than did congenital-type NMN.
Limitations |
Lack of systematic biopsy-proven diagnosis and heterogeneity of clinical and dermatoscopic photographs.
Conclusion |
Congenital and congenital-type NMN showed worrisome clinical and dermatoscopic features similar to those observed in adulthood subungual melanoma. The distal fibrillar (“brush-like”) pattern is a suggestive feature of congenital and congenital-type NMN.
Le texte complet de cet article est disponible en PDF.Key words : children, congenital, congenital nail matrix nevus, dermatoscopy, longitudinal melanonychia, melanonychia striata, nevus of the nail unit, pediatric, subungual melanoma
Abbreviations used : IDS, LM, NMN, SD, SUM
Plan
Funding sources: This work was supported in part by grants from Lyon 1 Claude Bernard University (to L.T.), The Hospices Civils de Lyon, France (to L.T.), and the foundation Vaincre le Mélanome (to L.T.). |
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IRB approval status: Reviewed and approved by the institutional ethical committee of Lyons (N°20-63). |
Vol 87 - N° 3
P. 551-558 - septembre 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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