Expression of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule (PECAM-1/CD31) in intestinal tuberculosis - 05/08/22
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Highlights |
• | Epithelioid cell granulomas have hypoxic microenvironment acting as a stimulus for angiogenesis. |
• | The significantly increased number of vessels were seen in the granulomatous areas compared to non-granulomatous areas indicating the role of neo-angiogenesis in disease pathogenesis. |
• | VEGF expression was markedly reduced in the mucosal epithelium of granulomatous area suggesting defective VEGF production by the intestinal epithelium making it prone to injury. |
• | Altered vasculature of the granuloma associated vessels might be a potential therapeutic target for intestinal TB in future, in conjunction with anti-tubercular treatment. |
Abbreviations : TB, Mtb, ITB, PTB, CD, IBD, LN, VEGF, PECAM1/CD31, IHC, MVD, HPF
Plan
Vol 135
Article 102229- juillet 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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