Expression of vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule (PECAM-1/CD31) in intestinal tuberculosis - 05/08/22
Doi : 10.1016/j.tube.2022.102229
Shilpi More a 
, Neelam Wadhwa a , Bhupendra K. Jain b , Kiran Mishra a, ⁎
, Neelam Wadhwa a , Bhupendra K. Jain b , Kiran Mishra a, ⁎ a Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, GTB Enclave, Dilshad Garden, New Delhi, Delhi, 110095, India
b Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, GTB Enclave, Dilshad Garden, New Delhi, Delhi, 110095, India
∗Corresponding author. D2, Bhim Nagri, SDA Block C3, New Delhi, 110016, India.D2Bhim NagriSDA Block C3New Delhi110016India
Highlights |
• | Epithelioid cell granulomas have hypoxic microenvironment acting as a stimulus for angiogenesis. |
• | The significantly increased number of vessels were seen in the granulomatous areas compared to non-granulomatous areas indicating the role of neo-angiogenesis in disease pathogenesis. |
• | VEGF expression was markedly reduced in the mucosal epithelium of granulomatous area suggesting defective VEGF production by the intestinal epithelium making it prone to injury. |
• | Altered vasculature of the granuloma associated vessels might be a potential therapeutic target for intestinal TB in future, in conjunction with anti-tubercular treatment. |
Abbreviations : TB, Mtb, ITB, PTB, CD, IBD, LN, VEGF, PECAM1/CD31, IHC, MVD, HPF
Plan
© 2022
Publié par Elsevier Masson SAS.
Vol 135
Article 102229- juillet 2022 Retour au numéro
Article précédent
- Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis
- Kusuma Sai Davuluri, Amit Kumar Singh, Vimal Kumar, Shoor Vir Singh, Ajay Vir Singh, Santhosh Kumar, Rajbala Yadav, Shweta Kushwaha, Devendra Singh Chauhan
- Activating transcription factor 3 protects alveolar epithelial type II cells from Mycobacterium tuberculosis infection-induced inflammation
- Bailing Zhang, Honglang Li, Jieling Zhang, Yaping Hang, Yi Xu
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?