Evaluating the diversity of circulating natural killer cells between active tuberculosis and latent tuberculosis infection - 05/08/22
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Abstract |
Tuberculosis (TB) is a leading global public health problem; however, the mechanisms underlying the immunopathology of TB progression are not well understood. It is currently believed that Mycobacterium tuberculosis (Mtb) infection can modify natural killer (NK) cell phenotypic signatures. Hence, our study was designed to investigate the diversity of circulating NK cells in patients with different TB infection status. NK subsets, as well as their expression of activating and inhibitory receptors between active TB (ATB) and latent TB infection (LTBI) were evaluated. There were significant differences in NK cell phenotypes between ATB, LTBI and healthy controls. Notably, the proportion of KLRG1 in NK cells (P = 0.036), as well as in their subsets CD56DimCD16+ (P = 0.046) and CD27+ (P = 0.027) NK cells, increased significantly in LTBI group than in ATB group; while Mtb specific IFN-γ+CD56BrightCD16Dim NK cells expressed higher KLRG1 in ATB than in LTBI (P = 0.027). However, the expression of activating receptor NKG2D in NK subsets showed no significant difference among the study groups. Our results suggest that different TB infection status are coupled with the diversity of NK cell compartments, and the expression of KLRG1 in NK cells may be a specific phenotype that modulates the progression of TB from latent to active.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Different TB infection status are coupled with the diversity of NK cell compartments. |
• | KLRG1+ NK is an important component affecting the immune balance between host and Mtb to keep TB latent. |
• | Mtb antigen-responsive NK cells tend to up-regulate KLRG1 expression during TB progression. |
• | The expression of NKG2D is associated with cytokine producing in TB-infected individuals. |
Keywords : Active tuberculosis, Latent tuberculosis infection, Natural killer cell, KLRG1, NKG2D
Abbreviations : TB, Mtb, NK, ATB, LTBI, HC, IGRAs, PBMCs, FMO, QFT-TB, PHA, PTB, EPTB
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Vol 135
Article 102221- juillet 2022 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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