Influence of the amount of skeletal muscle mass on rocuronium-induced neuromuscular block - 26/07/22
Abstract |
Objective |
To evaluate the effects of skeletal muscle mass on the rocuronium-induced neuromuscular block.
Design |
A prospective, double-blinded, observational study.
Setting |
A tertiary care university hospital.
Population |
One hundred one patients aged 18–65 years who were scheduled to undergo major surgery lasting more than 1 h under general anaesthesia.
Methods |
All participants underwent body composition analysis before anaesthesia and were allocated into two groups; the muscular and non-muscular group, according to skeletal muscle mass. During anaesthesia induction, rocuronium 1.0 mg kg−1 of total body weight was injected followed by neuromuscular monitoring using train-of-four stimulation every 15 s.
Main outcome measures |
The onset time of rocuronium included the elapsed time from the rocuronium injection until 95% depression of first twitch (T1) and the time to no response to TOF stimulation. The duration was evaluated as the elapsed time from the rocuronium injection to 25% recovery of the final T1 (TDUR25), and the time to the reappearance of T1 (TTOF1) and T4 (TTOF4). These pharmacologic data were compared between two groups.
Results |
There was no significant difference in the onset time of rocuronium between the two groups. However, TDUR25 (min) was significantly shorter in the muscular group than in the non-muscular group (p = 0.035 and p = 0.014 in males and females, respectively). TTOF1 and TTOF4 were also shorter in the muscular group than in the non-muscular group.
Conclusions |
Total body weight-based dosing of rocuronium might prolong the neuromuscular relaxation effect in patients with a small amount of skeletal muscle.
Le texte complet de cet article est disponible en PDF.Keywords : Body composition, Duration, Onset, Pharmacology, Rocuronium
Plan
Vol 41 - N° 4
Article 101086- août 2022 Retour au numéro
Article précédent
- A modified TOF-ratio to assess rocuronium-induced neuromuscular block: a comparison with the usual TOF-ratio
- Denis Schmartz, Paul Bernard, Raouf Sghaier, Jean-Francois Fils, Thomas Fuchs-Buder
- Rapid sequence induction with a “modified timing principle” of rocuronium provides excellent intubating conditions: A randomised trial
- Jie Wang, Xiaodan Han, Jing Cang, Changhong Miao, Chao Liang
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