Outcome predictors in SARS-CoV-2 disease (COVID-19): The prominent role of IL-6 levels and an IL-6 gene polymorphism in a western Sicilian population - 03/07/22
Doi : 10.1016/j.jinf.2022.04.043
Lydia Giannitrapani a, b, 1, Giuseppa Augello b, 1, Luigi Mirarchi a, Simona Amodeo a, Nicola Veronese a, Bruna Lo Sasso c, Rosaria Vincenza Giglio c, Anna Licata a, Mario Barbagallo a, Marcello Ciaccio c, Melchiorre Cervello b, ⁎ 
, Maurizio Soresi a, ⁎
, Maurizio Soresi a, ⁎ a Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy
b Institute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, Palermo 90146, Italy
c Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, Palermo, Italy
⁎Corresponding authors.
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Highlights |
• | Serum IL-6 levels predict COVID-19 disease severity and unfavorable outcomes. |
• | An IL-6 gene variant is a predictor of COVID-19 disease severity and unfavorable outcomes. |
• | Age and ischemic heart disease are important negative prognostic factors for COVID-19 disease. |
Abbreviations : COVID-19, GRS, IL-6, MX1, NLR, PSI, SARS-CoV-2
© 2022
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 85 - N° 2
P. 174-211 - août 2022 Retour au numéro
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