Surface electrostatic shift on spike protein decreased antibody activities against SARS-CoV-2 Omicron variant - 03/07/22
Doi : 10.1016/j.jinf.2022.04.033
Shu Yuan a, ⁎, 1 
, Si-Cong Jiang b, 1, Zhong-Wei Zhang a, 1, Yu-Fan Fu a, 1, Xin-Yue Yang a, 1, Zi-Lin Li c, Jing Hu d, Jun-Bo Du e, Ming Yuan f, Yang-Er Chen f
, Si-Cong Jiang b, 1, Zhong-Wei Zhang a, 1, Yu-Fan Fu a, 1, Xin-Yue Yang a, 1, Zi-Lin Li c, Jing Hu d, Jun-Bo Du e, Ming Yuan f, Yang-Er Chen f a College of Resources, Sichuan Agricultural University, Chengdu, China
b Haisco Pharmaceutical Group Comp. Ltd., Chengdu, China
c Department of Cardiovascular Surgery, Xijing Hospital, Medical University of the Air Force, Xi'an, China
d School of Medicine, Northwest University, Xi'an 710069, China
e College of Agronomy, Sichuan Agricultural University, Chengdu, China
f College of Life Science, Sichuan Agricultural University, Ya'an 625014, China
⁎Corresponding author.
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Highlights |
• | Antibodies against S2 subunit showed higher activity than the antibodies against RBD. |
• | Glycosylation-removing treatments weekly increased antibody activities. |
• | For the original strain, epitopes distribute on electrically neutral areas, which are positively charged in the Omicron strain. |
• | When pH was adjusted to 5.0, antibody titers against Omicron increased exponentially. |
© 2022
Publié par Elsevier Masson SAS.
Vol 85 - N° 2
P. 174-211 - août 2022 Retour au numéro
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